Actively Recruiting
Genomic Investigation of Unusual Responders
Led by University Health Network, Toronto · Updated on 2025-01-31
100
Participants Needed
1
Research Sites
626 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Studies have shown that tumors from the same patient may respond very differently to the same therapeutic agents. This study aims to investigate the genetic basis of tumors that respond abnormally well or poorly to therapeutic agents in an effort to understand the fundamental genetic basis of this response. The present protocol seeks to retrospectively perform Exome, next-generation (DNA) sequencing and/or other molecular techniques on tumor samples to identify the genetic basis of a patient's exceptional response to chemotherapy.
CONDITIONS
Official Title
Genomic Investigation of Unusual Responders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- The patient must have either an exceptionally good or poor response to treatment, as indicated by their treating physician.
- Exceptionally good response includes complete response, partial response, or progression-free interval of at least 6 months.
- Exceptionally poor response includes patients expected to respond well but instead had poor outcomes such as dramatic tumor growth or death.
- The patient must have sufficient archival tumor tissue available for sequencing.
- Deceased patients may be included if archival tissue is stored within the UHN Laboratory Medicine Program with consent waiver or within the UHN Biospecimen Sciences Program.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Princess Margaret Cancer Centre
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
Research Team
C
Celeste Yu
CONTACT
E
Elizabeth Shah
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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