Actively Recruiting
Genomic Predictors of Recurrent Pregnancy Loss
Led by Yale University · Updated on 2026-02-11
500
Participants Needed
10
Research Sites
273 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
J
Johns Hopkins University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The overall goals of this proposal are to determine the genetic architecture of recurrent pregnancy loss (RPL) and to discover genomic predictors of RPL.
CONDITIONS
Official Title
Genomic Predictors of Recurrent Pregnancy Loss
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women with loss of a current singleton pregnancy before 20 weeks gestation confirmed by ultrasound or tissue examination
- History of one or more prior pregnancy losses
- Current pregnancy confirmed as euploid by karyotype, microarray, or sequencing (some aneuploid losses allowed in pilot phase)
- Women with a history of three or more pregnancy losses of unknown cause, with or without a liveborn child
You will not qualify if you...
- History of parental karyotype abnormalities
- History of antiphospholipid antibody syndrome
- Evidence of uncontrolled diabetes
- Evidence of uncontrolled thyroid disease
- History of autoimmune disease related to pregnancy loss (e.g., systemic lupus erythematosus, rheumatoid arthritis)
- History of uterine anomalies
- History of cervical insufficiency
- Known cause of pregnancy loss
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
University of Colorado
Aurora, Colorado, United States, 80045
Actively Recruiting
2
Yale University
New Haven, Connecticut, United States, 06511
Actively Recruiting
3
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
4
University of Chicago
Chicago, Illinois, United States, 60611
Active, Not Recruiting
5
Gaelle Massoud
Baltimore, Maryland, United States, 21205
Actively Recruiting
6
Wayne State University
Detroit, Michigan, United States, 48201
Actively Recruiting
7
Columbia University
New York, New York, United States, 10032
Actively Recruiting
8
Pennsylvania State University
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
9
University of Texas at Austin
Austin, Texas, United States, 78712
Actively Recruiting
10
University of Texas at San Antonio
San Antonio, Texas, United States, 78299
Actively Recruiting
Research Team
Y
Yong-Hui Jiang, MD, PhD
CONTACT
H
Heping Zhang, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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