Actively Recruiting
Genotype, Phenotype, and Disease Progression of Developmental Epileptic Encephalopathy With Onset Before 2 Years of Age
Led by Number 2 Children's Hospital, Ho Chi Minh City · Updated on 2025-01-09
50
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the genotypes, phenotypes, and disease progression of developmental epileptic encephalopathy in Vietnamese children who develop the condition before 2 years of age. This severe form of epilepsy often leads to intellectual disability and autism spectrum disorders, especially when caused by genetic factors. Despite its high incidence and impact, there is limited research on this topic in Vietnam. The study follows children diagnosed with specific early-onset epileptic encephalopathies, including drug-resistant cases, as defined by international criteria. Participants are aged from birth up to 23 months at enrollment. Researchers will observe and analyze the genetic profiles and clinical features of these children over a two-year period to understand how the disease progresses. During the study, children will be monitored through genetic testing and clinical evaluations to track changes in their condition. The primary outcome being measured is the genotype associated with early-onset developmental epileptic encephalopathy, assessed between February 2024 and April 2025. This observational study aims to provide insights that may improve treatment and management strategies for affected children.
CONDITIONS
Brief Title
Genotype, Phenotype, and Disease Progression of Developmental Epileptic Encephalopathy With Onset Before 2 Years of Age
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with early infantile developmental and epileptic encephalopathy or epilepsy of infancy with migrating focal seizures or infantile spasms syndrome or severe myoclonic epilepsy of infancy or epilepsy with myoclonic-atonic seizures
- Diagnosed with drug-resistant epilepsy according to ILAE 2010 criteria
- Age at the start of participating in the study ranged from 0 to 23 months old
- Relatives agree to participate in the research
- No medical history of hypoxic encephalopathy, inflammatory encephalopathy, traumatic encephalopathy, cerebral infarction, or cerebral hemorrhage
You will not qualify if you...
- Patients lost to follow-up at 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 2 months
Participants undergo evaluations to confirm diagnosis of early-onset developmental epileptic encephalopathy and related syndromes according to established criteria.
1 to 2 visits depending on diagnostic procedures
Duration - Up to 4 years
Participants are monitored over time to observe genotype, phenotype, and disease progression, supporting early intervention and treatment planning.
Regular follow-up visits over the course of the study
Trial Site Locations
Total: 2 locations
1
Children hospital number 2
Ho Chi Minh City, Vietnam, 700000
Actively Recruiting
2
University of Medicine and Pharmacy at Ho Chi Minh city
Ho Chi Minh City, Vietnam
Actively Recruiting
Research Team
T
Thuy-Minh-Thu Thuy Minh NGUYEN, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here