Actively Recruiting
Genotype, Phenotype, and Disease Progression of Developmental Epileptic Encephalopathy With Onset Before 2 Years of Age
Led by Number 2 Children's Hospital, Ho Chi Minh City · Updated on 2025-01-09
50
Participants Needed
2
Research Sites
244 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
According to estimates by the World Health Organization in 2019, more than 50 million people around the world have epilepsy. Nearly 80% of patients with epilepsy live in developing countries. Among them, children under 2 years old are the group with the highest incidence of epilepsy, and at the same time, the most dangerous epilepsy groups are also likely to start at these ages. World medical literature on epileptic encephalopathy and early-onset development before 2 years of age records that 71% of children have severe intellectual disability and 60% of children show signs of autism spectrum disorder, of which Children with epileptic and developmental encephalopathy due to genetic causes are at higher risk of developing neurodevelopmental disorders than children with epileptic and developmental encephalopathy due to other causes. However, in Vietnam, there is no research on this topic. The question is what are the phenotypes, genotypes, and progression after 2 years of follow-up of Vietnamese children with epileptic and developmental encephalopathy with onset before 2 years of age?
CONDITIONS
Official Title
Genotype, Phenotype, and Disease Progression of Developmental Epileptic Encephalopathy With Onset Before 2 Years of Age
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with early infantile developmental epileptic encephalopathy or epilepsy of infancy with migrating focal seizures or infantile spasms syndrome or severe myoclonic epilepsy of infancy or epilepsy with myoclonic-atonic seizures
- Diagnosed with drug-resistant epilepsy according to ILAE 2010 criteria
- Age between 0 and 23 months at study start
- Relatives agree to participate in the research
- No medical history of hypoxic encephalopathy, inflammatory encephalopathy, traumatic encephalopathy, cerebral infarction, or cerebral hemorrhage
You will not qualify if you...
- Lost to follow-up at 6 months
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Children hospital number 2
Ho Chi Minh City, Vietnam, 700000
Actively Recruiting
2
University of Medicine and Pharmacy at Ho Chi Minh city
Ho Chi Minh City, Vietnam
Actively Recruiting
Research Team
T
Thuy-Minh-Thu Thuy Minh NGUYEN, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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