Actively Recruiting

Age: 60Years +
All Genders
ID03713853

Geriatric Acetabular Fractures: Open Reduction Internal Fixation Versus Replacement - A Large Cohort Study Comparing ORIF and Total Hip Arthroplasty for Older Adults

Led by Unity Health Toronto · Updated on 2025-12-24

104

Participants Needed

1

Research Sites

52 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to compare two surgical treatments for acetabular (hip) fractures in patients aged 60 years and older. Managing these fractures in the elderly is challenging due to pre-existing health issues, osteoporosis, and higher mortality risk. The study focuses on evaluating pain and physical function outcomes following different surgical approaches in this population. Participants will receive either acute primary total hip arthroplasty (THA) combined with open reduction internal fixation (ORIF) during the same surgery or ORIF alone, based on the surgeon's decision. This is an observational cohort study conducted across multiple academic centers affiliated with the Canadian Orthopaedic Trauma Society. Follow-up visits occur at 6 weeks, 3, 6, 12, and 24 months after surgery. During the study, patients will complete questionnaires such as the Oxford Hip Score to measure pain and function, and the European Quality of Life-5 Dimensions (EQ-5D) to assess quality of life. Functional mobility will be evaluated using the Timed Up & Go Test. Additional measures include pain levels, opioid use, hospital stay length, discharge location, time to full weight-bearing, return to work and daily activities, and hospital readmission within 30 days.

CONDITIONS

Brief Title

Geriatric Acetabular fracTures: Open Reduction Internal Fixation Versus Replacement

Who Can Participate

Age: 60Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • 60 years of age or older
  • Isolated and displaced acetabular fracture (2mm or more displacement on any x-ray view)
  • Requires surgical treatment with either total hip arthroplasty combined with ORIF or ORIF alone
  • Fracture occurred within 3 weeks of injury
  • Was able to walk before the fracture, with or without walking aids
  • Able to provide informed consent
  • Able to read and understand English
Not Eligible

You will not qualify if you...

  • Active or chronic infection near the fracture site (soft tissue or bone)
  • Open or compound fracture
  • Fractures on both acetabula (bilateral)
  • Pathological fractures other than osteoporosis
  • Periprosthetic fractures (existing implants or previous ORIF at the fracture site)
  • Medical or surgical reasons that prevent surgery
  • Diagnosis of dementia

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Surgery and Immediate Post-operative Care

Duration - Up to 30 days

Participants undergo surgery to treat their acetabular fracture with either total hip arthroplasty combined with open reduction internal fixation or open reduction internal fixation alone. Post-operative care includes hospital stay and initial recovery.

Daily assessments during hospital stay

Post-operative Follow-up

Duration - Up to 24 months

Participants are followed up as per standard of care to monitor recovery and assess outcomes such as pain, mobility, and quality of life.

Visits at 6 weeks, 3, 6, 12, and 24 months

Trial Site Locations

Total: 1 location

1

Unity Health Toronto - St Michael's Hospital

Toronto, Ontario, Canada, M5C 1R6

Actively Recruiting

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Research Team

C

Cassandra Tardif-Theriault, BKin

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Frequently Asked Questions

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Published Research Related To This Trial

Comparison of open reduction and internal fixation and primary total hip replacement for osteoporotic acetabular fractures: a retrospective clinical study.

Sebastian P Boelch, Martin C Jordan, Rainer H Meffert...

https://pubmed.ncbi.nlm.nih.gov/27511470

Total Hip Arthroplasty After Acetabular Fracture Is Associated With Lower Survivorship and More Complications.

Zachary Morison, Dirk Jan F Moojen, Aaron Nauth...

https://pubmed.ncbi.nlm.nih.gov/26335343

Total Hip Arthroplasty for Posttraumatic Osteoarthritis of the Hip Fares Worse Than THA for Primary Osteoarthritis.

Sonya Khurana, Tamar B Nobel, Justin S Merkow...

https://pubmed.ncbi.nlm.nih.gov/26161760

Risk of Hip Arthroplasty After Open Reduction Internal Fixation of a Fracture of the Acetabulum: A Matched Cohort Study.

Patrick D G Henry, Sam Si-Hyeong Park, J Michael Paterson...

https://pubmed.ncbi.nlm.nih.gov/29462122

Does Total Hip Arthroplasty Reduce the Risk of Secondary Surgery Following the Treatment of Displaced Acetabular Fractures in the Elderly Compared to Open Reduction Internal Fixation? A Pilot Study.

Michael J Weaver, Raymond Malcolm Smith, David W Lhowe...

https://pubmed.ncbi.nlm.nih.gov/29373451

Should Total Hip Arthroplasty be Performed Acutely in the Treatment of Acetabular Fractures in Elderly or Used as a Salvage Procedure Only?

Katharine Hamlin, Gabija Lazaraviciute, Michalis Koullouros...

https://pubmed.ncbi.nlm.nih.gov/28790471