Actively Recruiting
Getting Under the Skin of the Menopausal Hot Flush
Led by Liverpool John Moores University · Updated on 2025-03-18
36
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
L
Liverpool John Moores University
Lead Sponsor
B
British Heart Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this research is to 1) test how the skin blood vessels and sweat glands function in women who experience hot flushes by using skin microdialysis to deliver small amounts of substances to the skin that cause increased skin blood flow and sweating, and 2) examine the structure of the skin blood vessels and sweat glands in the skin of women who experience hot flushes by taking a very small skin biopsy. Any changes in the function or structure of the skin blood vessels or sweat glands in women with hot flushes would increase our understanding of what causes hot flushes and help to design effective treatments.
CONDITIONS
Official Title
Getting Under the Skin of the Menopausal Hot Flush
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female
- Aged over 45 years for postmenopausal or aged 18-30 years for premenopausal
- Amenorrhoeic for more than 6 months if postmenopausal
- Experiencing more than 4 hot flushes per day if postmenopausal
- Regular menstrual cycles if premenopausal
- Healthy overall
- Non-smoker
- Body Mass Index (BMI) between 18 and 30 kg/m2
- No history of cardiovascular or respiratory disease
- No history of metabolic diseases such as type II diabetes
- Drinking less than 14 units of alcohol per week
- Not taking any medication or treatments to relieve hot flushes
You will not qualify if you...
- Aged under 18 years or between 31 and 44 years
- Male
- Smoker
- History of cardiovascular or respiratory disease
- History of metabolic diseases such as type II diabetes
- Drinking more than 15 units of alcohol per week
- Taking or have taken medication or treatments for hot flushes within the past 6 months
- Body Mass Index (BMI) below 18 or above 30 kg/m2
- Vaccination within the last week
- Local forearm infection
- Allergy to local anaesthetic, Marcain, or amide-group anaesthetics
- Pregnant
AI-Screening
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Trial Site Locations
Total: 1 location
1
Liverpool John Moores University
Liverpool, Merseyside, United Kingdom, L3 3AF
Actively Recruiting
Research Team
K
Kirsty A. Roberts, PhD
CONTACT
D
David A Low, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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