Actively Recruiting
GI Oxalate Absorption
Led by University of Chicago · Updated on 2025-08-19
30
Participants Needed
1
Research Sites
183 weeks
Total Duration
On this page
Sponsors
U
University of Chicago
Lead Sponsor
U
University of Alabama at Birmingham
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week. For the first two days, subjects will be asked to eat a special diet at home. From Days 3-5, they will eat special meals delivered to their home from a research clinic at the University of Chicago. They will also collect 24-hour urine samples at home on Days 4 and 5. On Day 6, they will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. They will receive a special liquid that contains oxalate, and we will have them eat a specially prepared breakfast that is low in oxalate and citrate.
CONDITIONS
Official Title
GI Oxalate Absorption
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 70 years
- Post-Roux-en-Y gastric bypass stone formers with history of at least one calcium-based kidney stone after surgery and urine oxalate above normal range
- Obese stone formers with BMI 30 kg/m2 or higher, history of at least one calcium-based kidney stone, and urine oxalate above normal range
- Non-obese stone formers with BMI between 18.5 and 29.9 kg/m2 and history of at least one calcium-based kidney stone
You will not qualify if you...
- Post-Roux-en-Y gastric bypass stone formers with history of colon resection, duodenal switch bowel surgery, ileal-jejunal bypass surgery, or primarily uric acid, cysteine, or struvite stones
- Obese and non-obese stone formers with history of bowel surgery, colon resection, inflammatory bowel disease (Crohn's disease, Ulcerative Colitis), or primarily uric acid, cysteine, or struvite stones
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Chicago Medical Center
Chicago, Illinois, United States, 60637
Actively Recruiting
Research Team
M
Megan Prochaska, MD
CONTACT
E
Elaine Worcester, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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