Actively Recruiting
Giant Cell Arteritis - Ways to Precision Medicine
Led by Wuerzburg University Hospital · Updated on 2025-12-22
400
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients with Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR) to better understand long-term risks and side effects associated with these conditions and their treatments. The study focuses on tracking aortic adverse events like aneurysms and dissections as well as side effects linked to glucocorticoid use over a period of 5 to 10 years. It also aims to identify patient groups using imaging, clinical exams, blood markers, and immune cell testing to help personalize therapy. This observational study follows two groups: patients already receiving immunosuppressive therapy with regular outpatient visits, and new patients, including those not previously treated. The study evaluates the usefulness of imaging techniques such as orbital MRI with eye exams for detecting ischemic complications, and tests a new MRI method that uses less contrast agent. It also investigates whether certain immune cells can predict disease recurrence or help monitor therapy. Participants will undergo regular clinical exams, imaging scans, blood tests, and eye assessments over a 5-year period. Researchers will monitor the occurrence of aortic events, glucocorticoid-related side effects, ischemic eye complications, and the performance of the MRI contrast agent. The study's long-term follow-up helps to gather detailed information on disease progression, treatment impact, and potential ways to tailor therapies more precisely for individuals.
CONDITIONS
Brief Title
Giant Cell Arteritis - Ways to Precision Medicine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Primary diagnosis of Giant Cell Arteritis or Polymyalgia Rheumatica
You will not qualify if you...
- Under 18 years of age
- Lack of capacity to consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 5 to 10 years
Participants who have Giant Cell Arteritis or Polymyalgia Rheumatica are observed over several years with regular imaging, clinical examinations, and laboratory tests to assess risks and disease progression.
Regular visits for assessments over 5 to 10 years
Trial Site Locations
Total: 1 location
1
Universitätsklinikum Würzburg
Würzburg, Germany
Actively Recruiting
Research Team
M
Michael Gernert
H
Hannah Labinsky
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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