Long-Term Monitoring of Aortic and Glucocorticoid-Related Effects in Giant Cell Arteritis and Polymyalgia Rheumatica Patients

What this Trial Is About

Researchers are studying patients with Giant Cell Arteritis GCA and Polymyalgia Rheumatica PMR to better understand long-term risks and side effects associated with these conditions and their treatments. The study focuses on tracking aortic adverse events like aneurysms and dissections as well as side effects linked to glucocorticoid use over a period of 5 to 10 years. It also aims to identify patient groups using imaging, clinical exams, blood markers, and immune cell testing to help personalize therapy. This observational study follows two groups patients already receiving immunosuppressive therapy with regular outpatient visits, and new patients, including those not previously treated. The study evaluates the usefulness of imaging techniques such as orbital MRI with eye exams for detecting ischemic complications, and tests a new MRI method that uses less contrast agent. It also investigates whether certain immune cells can predict disease recurrence or help monitor therapy. Participants will undergo regular clinical exams, imaging scans, blood tests, and eye assessments over a 5-year period. Researchers will monitor the occurrence of aortic events, glucocorticoid-related side effects, ischemic eye complications, and the performance of the MRI contrast agent. The studys long-term follow-up helps to gather detailed information on disease progression, treatment impact, and potential ways to tailor therapies more precisely for individuals.

Giant Cell Arteritis - Ways to Precision Medicine