Glaucoma rehabilitation with action video games and exercise: study protocol of an active-controlled trial (GRADE).
Peng Yihong, Benjamin Thompson, Stanley Winser...
https://pubmed.ncbi.nlm.nih.gov/40967649Actively Recruiting
Phase Not Applicable
Age: 55Years - 80Years
All Genders
ID06000865
The GRADE Randomized Trial: Glaucoma Rehabilitation With Action Video Games and Exercise
Led by The Hong Kong Polytechnic University · Updated on 2025-07-28
56
Participants Needed
1
Research Sites
21 weeks
Total Duration
On this page
Sponsors
T
The Hong Kong Polytechnic University
Lead Sponsor
U
University of Waterloo
Collaborating Sponsor
AI-Summary
What this Trial Is About
Falls are a major health concern for older adults, especially those with glaucoma who experience peripheral vision loss that affects their mobility and balance. This research evaluates a new, enjoyable video game-based intervention designed to improve movement and postural control in glaucoma patients with moderate to severe peripheral vision loss. The study aims to reduce fall risk and improve quality of life by incorporating this intervention into existing vision and balance rehabilitation programs. This clinical trial randomly assigns 56 glaucoma patients with stable peripheral vision loss to two groups. One group participates in 20 sessions of standing, physically interactive action video-game training using a Nintendo Switch, with games involving muscle stretching and strengthening exercises, conducted twice weekly for 10 weeks. The other group receives 20 sessions of conventional physical training, also lasting 45 minutes twice per week for 10 weeks. Both interventions are compared to assess their effects on mobility and balance. Participants will be evaluated before starting, after 10 sessions, and after 20 sessions. Assessments include a primary mobility test combining walking and timed up and go tasks, as well as secondary tests of static and dynamic balance, visual cognition, reaction time, cognitive reflection, and questionnaires on fear of falling and quality of life. The study includes regular monitoring of participant progress over the 10-week intervention period.
CONDITIONS
Brief Title
Glaucoma Rehabilitation With Action viDeo Games and Exercise - GRADE
Who Can Participate
Age: 55Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- Age between 55 and 80 years
- Moderate to severe bilateral glaucomatous optic neuropathy diagnosed by an ophthalmologist
- Stable vision and visual field loss for at least 3 months
- Best-corrected distance visual acuity of 6/12 or better
- Cognitive functional score of 22 or above on the Montreal Cognitive Assessment - Hong Kong version
You will not qualify if you...
- Advanced glaucoma with median deviation worse than -25 decibel
- Other eye diseases such as age-related macular degeneration, diabetic retinopathy, or moderate to severe cataract
- Severe medical problems like stroke or Parkinson's disease
- Neurological disorders such as brain surgery, brain tumor, or peripheral neuropathy
- Cognitive disorders including diagnosed dementia or cognitive impairment
- Physical impairments requiring orthopedic or mobility aids
- Vestibular or cerebellar dysfunction, history of vertigo, or severe hearing loss
- Use of medications for neurological or psychiatric conditions that affect motor control
- Currently attending intensive physical or balance training
AI-Screening
AI-Powered Screening
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2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Outpatient Treatment
Duration - 10 weeks
Participants receive 20 sessions of either standing action video-game training or conventional physical training over 10 weeks.
Twice weekly sessions for 10 weeks
Follow-up Assessments
Duration - Concurrent with treatment period
Outcome measures including mobility, balance, visual cognition, and quality of life are assessed before training, after 10 sessions (week 5), and after 20 sessions (week 10).
3 assessment visits (baseline, week 5, and week 10)
Trial Site Locations
Total: 1 location
1
The Hong Kong Polytechnic University
Hong Kong, Hong Kong, Hong Kong, 000000
Actively Recruiting
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Research Team
A
Allen Cheong, PhD
M
Mable Tong, BSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
OTHER
Number of Arms
2
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