Actively Recruiting
Global Burden Estimation of Human Papillomavirus (GLOBE-HPV)
Led by International Vaccine Institute · Updated on 2025-07-16
29750
Participants Needed
8
Research Sites
209 weeks
Total Duration
On this page
Sponsors
I
International Vaccine Institute
Lead Sponsor
L
London School of Hygiene and Tropical Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is a multi-country and multi-site project to estimate the point-prevalence of high-risk (HR) HPV genotype infections among representative samples of girls and women aged 9-50 years, and among specific sub-populations to estimate the incidence of persistent HPV infection among sexually active young women. The data to fulfill the objectives will be collected through a series of Cross-Sectional Surveys (CSS) and Longitudinal Studies (LS) in all 8 countries 3 South Asian countries including Bangladesh, Pakistan, Nepal and 5 sub-Saharan African countries including Sierra Leone, Tanzania, Ghana, Zambia and DR Congo. Qualitative sub-studies (QS) will be conducted in selected countries and populations following the CSS to further understand and unpack risk factors for HPV infection as well as to explore how gender-related dynamics including perceptions of gender norms and stigma, influence HPV burden and/or create barriers that shape girls/women access to and uptake of HPV prevention, screening, and treatment services. Specific study protocols and corresponding ethical applications for the qualitative sub-studies will be developed separately.
CONDITIONS
Official Title
Global Burden Estimation of Human Papillomavirus (GLOBE-HPV)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 9 to 50 years at enrollment
- Resident in the selected community for at least the past 3 months (exceptions apply for pastoralists, refugees, and commercial sex workers)
- Able to understand the study purpose and procedures
- Able and willing to provide informed consent if 18 years or older or an emancipated minor
- If under 18 and not emancipated, must have parent or guardian consent and able to provide assent
You will not qualify if you...
- Decline to consent to participate in any study activity
- Have a medical condition or other reason that prevents enrollment as judged by the investigator, not related to HPV infection or HPV-related diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 8 locations
1
Diarrhoeal Disease Research, Bangladesh (icddr,b)
Dhaka, Bangladesh, 1212
Completed
2
Institut National pour la Recherche Biomedicale (INRB)
Kinshasa, Democratic Republic of the Congo
Actively Recruiting
3
University of Health and Allied Sciences (UHAS)
Ho, Volta Region, Ghana
Completed
4
Dhulikhel Hospital Kathmandu University Hospital (DHKUH)
Dhulikhel, Nepal, 45200
Completed
5
Aga Khan University (AKU)
Karachi, Pakistan, 74800
Completed
6
College of Medicine and Allied Health Sciences (COMAHS)
Freetown, Sierra Leone
Completed
7
Mwanza Intervention Trial Unit (MITU)
Mwanza, Tanzania, 11936
Completed
8
ZAMBART
Lusaka, Zambia
Completed
Research Team
J
Julia Lynch
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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