Actively Recruiting
A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma Based on Organ Sparing and Mininvasivity
Led by Fondazione del Piemonte per l'Oncologia · Updated on 2026-03-05
200
Participants Needed
1
Research Sites
348 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A phase II, single-center, non-profit, interventional study on patients affected by rectal adenocarcinoma. Patients will be stratified into three groups based on pre-treatment clinical stage. The study investigates and may propose a comprehensive, stage-specific, multimodal approach to rectal adenocarcinoma, with a focus on organ preservation even in early stages (cT1-2N0). When organ-sparing strategies are not feasible, the approach prioritizes minimally invasive techniques (laparoscopic and robotic) to reduce the physical, psychological, and quality-of-life impact on patients.
CONDITIONS
Official Title
A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma Based on Organ Sparing and Mininvasivity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged �3e�3d18 years old
- Patients able to sign the informed consent
- Patients with High Risk pT1 rectal adenocarcinoma endoscopically excised
- Patients with cT2-3aN0 rectal adenocarcinoma who have complete or major response to experimental chemoradiotherapy
- Patients with cT3b-4N0-1 rectal adenocarcinoma who have complete or major response to standard chemoradiotherapy
You will not qualify if you...
- Patients with cT2-4 any NM0 tumors who do not reach clinical complete response (cCR) or clinical minimal residual disease (cMR) after experimental or standard chemoradiotherapy
- Pregnancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Department of Surgical Oncology - FPO-IRCCS Institute for Cancer Research and Treatment
Candiolo, Turin, Italy, 10060
Actively Recruiting
Research Team
A
Alfredo Mellano, MD
CONTACT
A
Annamaria Nuzzo, PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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