Actively Recruiting
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC
Led by AstraZeneca · Updated on 2026-03-27
878
Participants Needed
282
Research Sites
277 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of ARTEMIDE-Lung03 is to evaluate the efficacy and safety of rilvegostomig compared to pembrolizumab, both in combination with platinum-based doublet chemotherapy, as a first-line treatment of patients with non-squamous mNSCLC whose tumors express PD-L1.
CONDITIONS
Official Title
A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Metastatic Non-squamous NSCLC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically or cytologically documented non-squamous NSCLC
- Stage IV metastatic NSCLC not suitable for curative treatment
- No sensitizing EGFR mutations or ALK and ROS1 rearrangements
- No other actionable driver oncogenes with approved targeted therapies
- Tumor PD-L1 expression of 1% or higher confirmed by acceptable tumor sample
- At least one measurable lesion not previously irradiated suitable for repeated measurement
- Adequate organ and bone marrow function
You will not qualify if you...
- Presence of small cell or neuroendocrine histology components
- Brain metastases unless asymptomatic, stable, and no steroid or anticonvulsant use for at least 7 days prior
- Less than 2 weeks since end of brain radiotherapy or surgery or not recovered from acute effects
- Prior systemic therapy for advanced or metastatic NSCLC (except certain prior neoadjuvant/adjuvant treatment with progression over 12 months)
- Prior exposure to anti-TIGIT or other immune-regulatory anticancer therapies
- Prior treatment with anti-PD-1 or anti-PD-L1 agents
- History of other primary malignancy within 2 years unless treated with curative intent and low recurrence risk
- Active or prior autoimmune or inflammatory disorders requiring chronic immunosuppressive treatment
- Active primary immunodeficiency or infectious disease
- Active tuberculosis infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 282 locations
1
Research Site
Mobile, Alabama, United States, 36608
Actively Recruiting
2
Research Site
Chandler, Arizona, United States, 85224
Withdrawn
3
Research Site
Phoenix, Arizona, United States, 85054
Actively Recruiting
4
Research Site
Anaheim, California, United States, 92801
Actively Recruiting
5
Research Site
Beverly Hills, California, United States, 90211
Actively Recruiting
6
Research Site
Loma Linda, California, United States, 92350
Not Yet Recruiting
7
Research Site
Redlands, California, United States, 92373
Actively Recruiting
8
Research Site
San Diego, California, United States, 92123
Actively Recruiting
9
Research Site
San Francisco, California, United States, 94121
Actively Recruiting
10
Research Site
Santa Rosa, California, United States, 95403
Actively Recruiting
11
Research Site
Walnut Creek, California, United States, 94598
Actively Recruiting
12
Research Site
Lone Tree, Colorado, United States, 80124
Actively Recruiting
13
Research Site
Stamford, Connecticut, United States, 06902
Actively Recruiting
14
Research Site
West Haven, Connecticut, United States, 06516
Actively Recruiting
15
Research Site
Newark, Delaware, United States, 19713
Actively Recruiting
16
Research Site
Bay Pines, Florida, United States, 33744
Actively Recruiting
17
Research Site
Fort Lauderdale, Florida, United States, 33308
Actively Recruiting
18
Research Site
Gainesville, Florida, United States, 32610
Withdrawn
19
Research Site
Jacksonville, Florida, United States, 32224
Actively Recruiting
20
Research Site
Miami, Florida, United States, 33125
Actively Recruiting
21
Research Site
Ocala, Florida, United States, 34474
Not Yet Recruiting
22
Research Site
St. Petersburg, Florida, United States, 33709
Actively Recruiting
23
Research Site
Atlanta, Georgia, United States, 30342
Withdrawn
24
Research Site
Boise, Idaho, United States, 83712
Actively Recruiting
25
Research Site
Chicago, Illinois, United States, 60637
Actively Recruiting
26
Research Site
Decatur, Illinois, United States, 62526
Actively Recruiting
27
Research Site
Hinsdale, Illinois, United States, 60521
Actively Recruiting
28
Research Site
Quincy, Illinois, United States, 62305
Actively Recruiting
29
Research Site
Rockford, Illinois, United States, 61114
Withdrawn
30
Research Site
Waterloo, Iowa, United States, 50702
Actively Recruiting
31
Research Site
Lexington, Kentucky, United States, 40509
Actively Recruiting
32
Research Site
Lexington, Kentucky, United States, 40536
Withdrawn
33
Research Site
Louisville, Kentucky, United States, 40207
Actively Recruiting
34
Research Site
Alexandria, Louisiana, United States, 71301
Withdrawn
35
Research Site
Baton Rouge, Louisiana, United States, 70808
Not Yet Recruiting
36
Research Site
Shreveport, Louisiana, United States, 71103
Actively Recruiting
37
Research Site
Shreveport, Louisiana, United States, 71105
Actively Recruiting
38
Research Site
South Portland, Maine, United States, 04106
Not Yet Recruiting
39
Research Site
Baltimore, Maryland, United States, 21202
Actively Recruiting
40
Research Site
Grand Rapids, Michigan, United States, 49503
Actively Recruiting
41
Research Site
Duluth, Minnesota, United States, 55805
Withdrawn
42
Research Site
Rochester, Minnesota, United States, 55905
Actively Recruiting
43
Research Site
Saint Paul, Minnesota, United States, 55102
Actively Recruiting
44
Research Site
Bridgeton, Missouri, United States, 63044
Actively Recruiting
45
Research Site
Columbia, Missouri, United States, 65212
Withdrawn
46
Research Site
Lincoln, Nebraska, United States, 68506
Actively Recruiting
47
Research Site
Camden, New Jersey, United States, 08103
Actively Recruiting
48
Research Site
Buffalo, New York, United States, 14221
Actively Recruiting
49
Research Site
Westbury, New York, United States, 11590
Actively Recruiting
50
Research Site
Canton, Ohio, United States, 44710
Actively Recruiting
51
Research Site
Medford, Oregon, United States, 97504
Actively Recruiting
52
Research Site
Portland, Oregon, United States, 97239
Withdrawn
53
Research Site
Salem, Oregon, United States, 97301
Actively Recruiting
54
Research Site
Pittsburgh, Pennsylvania, United States, 15212
Withdrawn
55
Research Site
York, Pennsylvania, United States, 17403
Actively Recruiting
56
Research Site
Providence, Rhode Island, United States, 02903
Withdrawn
57
Research Site
Pierre, South Dakota, United States, 57501
Actively Recruiting
58
Research Site
Sioux Falls, South Dakota, United States, 57105
Actively Recruiting
59
Research Site
Chattanooga, Tennessee, United States, 37404
Actively Recruiting
60
Research Site
Nashville, Tennessee, United States, 37203
Actively Recruiting
61
Research Site
Fort Worth, Texas, United States, 76104
Actively Recruiting
62
Research Site
Houston, Texas, United States, 77090
Withdrawn
63
Research Site
Irving, Texas, United States, 75063
Actively Recruiting
64
Research Site
Kingwood, Texas, United States, 77339
Actively Recruiting
65
Research Site
Lubbock, Texas, United States, 79410
Withdrawn
66
Research Site
Palestine, Texas, United States, 75801
Actively Recruiting
67
Research Site
Round Rock, Texas, United States, 78665
Actively Recruiting
68
Research Site
Fairfax, Virginia, United States, 22031
Actively Recruiting
69
Research Site
Norfolk, Virginia, United States, 23502
Actively Recruiting
70
Research Site
Roanoke, Virginia, United States, 24014
Actively Recruiting
71
Research Site
Seattle, Washington, United States, 98101
Actively Recruiting
72
Research Site
Seattle, Washington, United States, 98104
Withdrawn
73
Research Site
Silverdale, Washington, United States, 98383
Actively Recruiting
74
Research Site
Spokane, Washington, United States, 99208
Actively Recruiting
75
Research Site
Tacoma, Washington, United States, 98405
Actively Recruiting
76
Research Site
Wenatchee, Washington, United States, 98801
Withdrawn
77
Research Site
La Crosse, Wisconsin, United States, 54601
Withdrawn
78
Research Site
Buenos Aires, Argentina, C1431FWO
Actively Recruiting
79
Research Site
CABA, Argentina, 1425
Actively Recruiting
80
Research Site
La Plata, Argentina, 1900
Withdrawn
81
Research Site
Pilar, Argentina, B1629ODT
Actively Recruiting
82
Research Site
Rosario, Argentina, S2000DEJ
Actively Recruiting
83
Research Site
Darlinghurst, Australia, 2010
Actively Recruiting
84
Research Site
Hyde Park, Australia, 4812
Actively Recruiting
85
Research Site
Southport, Australia, 4215
Actively Recruiting
86
Research Site
Wollongong, Australia, 2500
Actively Recruiting
87
Research Site
Brussels, Belgium, 1160
Actively Recruiting
88
Research Site
Charleroi, Belgium, 6060
Actively Recruiting
89
Research Site
Kortrijk, Belgium, 8500
Actively Recruiting
90
Research Site
Ottignies, Belgium, 1340
Actively Recruiting
91
Research Site
Sint-Niklaas, Belgium, 9100
Withdrawn
92
Research Site
Ijuí, Brazil, 98700-000
Actively Recruiting
93
Research Site
Londrina, Brazil, 86015-520
Actively Recruiting
94
Research Site
Passo Fundo, Brazil, 99010-260
Actively Recruiting
95
Research Site
Porto Alegre, Brazil, 91350-200
Actively Recruiting
96
Research Site
Salvador, Brazil, 40050 410
Actively Recruiting
97
Research Site
São Paulo, Brazil, 01246-000
Withdrawn
98
Research Site
São Paulo, Brazil, 01327-001
Actively Recruiting
99
Research Site
São Paulo, Brazil, 05652000
Actively Recruiting
100
Research Site
Taubaté, Brazil, 12030-200
Withdrawn
101
Research Site
Vitória, Brazil, 29043-260
Actively Recruiting
102
Research Site
Saint John, New Brunswick, Canada, E2L 4L2
Actively Recruiting
103
Research Site
Sydney, Nova Scotia, Canada, B1P 1P3
Withdrawn
104
Research Site
Hamilton, Ontario, Canada, L8V 1C3
Actively Recruiting
105
Research Site
Kingston, Ontario, Canada, K7L 2V7
Actively Recruiting
106
Research Site
Sault Ste. Marie, Ontario, Canada, P6A 0A8
Actively Recruiting
107
Research Site
Montreal, Quebec, Canada, H2X 0A9
Actively Recruiting
108
Research Site
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
109
Research Site
Saint-Jérôme, Quebec, Canada, J7Z 2V4
Actively Recruiting
110
Research Site
Beijing, China, 100021
Actively Recruiting
111
Research Site
Beijing, China, 100029
Actively Recruiting
112
Research Site
Beijing, China, CN-100730
Actively Recruiting
113
Research Site
Changchun, China, 130012
Actively Recruiting
114
Research Site
Changsha, China, 410013
Not Yet Recruiting
115
Research Site
Chengdu, China, 610041
Actively Recruiting
116
Research Site
Chongqing, China, 400030
Actively Recruiting
117
Research Site
Fuzhou, China, 350007
Actively Recruiting
118
Research Site
Guangzhou, China, 510062
Actively Recruiting
119
Research Site
Guangzhou, China, 510180
Actively Recruiting
120
Research Site
Hangzhou, China, 310003
Actively Recruiting
121
Research Site
Hangzhou, China, 310016
Actively Recruiting
122
Research Site
Hangzhou, China, 310022
Actively Recruiting
123
Research Site
Harbin, China, 150081
Actively Recruiting
124
Research Site
Hefei, China, 230601
Actively Recruiting
125
Research Site
Jinan, China, 250117
Active, Not Recruiting
126
Research Site
Jingzhou, China, 434000
Actively Recruiting
127
Research Site
Kunming, China, 650118
Actively Recruiting
128
Research Site
Linhai, China, 317000
Actively Recruiting
129
Research Site
Nanchang, China, 330008
Actively Recruiting
130
Research Site
Ningbo, China, 315010
Actively Recruiting
131
Research Site
Shanghai, China, 200030
Actively Recruiting
132
Research Site
Shanghai, China, 200433
Not Yet Recruiting
133
Research Site
Wenzhou, China, CN-325000
Actively Recruiting
134
Research Site
Wuhan, China, 430000
Actively Recruiting
135
Research Site
Xi'an, China, 710061
Actively Recruiting
136
Research Site
Xiangyang, China, 441000
Actively Recruiting
137
Research Site
Zhengzhou, China, 450008
Actively Recruiting
138
Research Site
Zhengzhou, China, 450052
Actively Recruiting
139
Research Site
Avignon, France, 84902
Actively Recruiting
140
Research Site
La Rochelle, France, 17019
Actively Recruiting
141
Research Site
Lyon, France, 69373
Actively Recruiting
142
Research Site
Nîmes, France, 30029
Actively Recruiting
143
Research Site
Rennes, France, 35033
Actively Recruiting
144
Research Site
Strasbourg, France, 67091
Actively Recruiting
145
Research Site
Suresnes, France, 92150
Actively Recruiting
146
Research Site
Toulon, France, 83800
Actively Recruiting
147
Research Site
Bad Berka, Germany, 99437
Actively Recruiting
148
Research Site
Berlin, Germany, 13585
Actively Recruiting
149
Research Site
Cologne, Germany, 51109
Actively Recruiting
150
Research Site
Esslingen am Neckar, Germany, 73730
Actively Recruiting
151
Research Site
Frankfurt, Germany, 60488
Actively Recruiting
152
Research Site
Gauting, Germany, 82131
Actively Recruiting
153
Research Site
Giessen, Germany, 35392
Actively Recruiting
154
Research Site
Großhansdorf, Germany, 22927
Actively Recruiting
155
Research Site
Hamburg, Germany, 20251
Actively Recruiting
156
Research Site
Hanover, Germany, 30459
Actively Recruiting
157
Research Site
Hanover, Germany, 30625
Actively Recruiting
158
Research Site
Hemer, Germany, 58675
Actively Recruiting
159
Research Site
Homburg, Germany, 66424
Actively Recruiting
160
Research Site
Kassel, Germany, 34125
Actively Recruiting
161
Research Site
Kiel, Germany, 24105
Actively Recruiting
162
Research Site
Krefeld, Germany, 47805
Actively Recruiting
163
Research Site
Minden, Germany, 32429
Actively Recruiting
164
Research Site
Moers, Germany, 47441
Actively Recruiting
165
Research Site
München, Germany, 81925
Not Yet Recruiting
166
Research Site
Regensburg, Germany, 93053
Actively Recruiting
167
Research Site
Würzburg, Germany, 97067
Actively Recruiting
168
Research Site
Budapest, Hungary, 1083
Not Yet Recruiting
169
Research Site
Budapest, Hungary, 1121
Actively Recruiting
170
Research Site
Budapest, Hungary, 1122
Actively Recruiting
171
Research Site
Debrecen, Hungary, 4032
Actively Recruiting
172
Research Site
Gyöngyös, Hungary, 3200
Withdrawn
173
Research Site
Gyöngyös - Mátraháza, Hungary, 3200
Actively Recruiting
174
Research Site
Győr, Hungary, 9024
Actively Recruiting
175
Research Site
Pécs, Hungary, 7624
Actively Recruiting
176
Research Site
Székesfehérvár, Hungary, 8000
Withdrawn
177
Research Site
Törökbálint, Hungary, 2045
Actively Recruiting
178
Research Site
Calicut, India, 673601
Actively Recruiting
179
Research Site
Delhi, India, 110029
Actively Recruiting
180
Research Site
Kolkata, India, 700054
Withdrawn
181
Research Site
Madurai, India, 625107
Actively Recruiting
182
Research Site
Mumbai, India, 400012
Not Yet Recruiting
183
Research Site
Nashik, India, 422002
Actively Recruiting
184
Research Site
New Delhi, India, 110075
Withdrawn
185
Research Site
Varanasi, India, 221005
Actively Recruiting
186
Research Site
Florence, Italy, 50134
Actively Recruiting
187
Research Site
Monza, Italy, 20052
Actively Recruiting
188
Research Site
Peschiera del Garda, Italy, 37019
Actively Recruiting
189
Research Site
Rome, Italy, 00168
Actively Recruiting
190
Research Site
Amagasaki-shi, Japan, 660-8550
Actively Recruiting
191
Research Site
Bunkyō City, Japan, 113-8603
Actively Recruiting
192
Research Site
Chūōku, Japan, 104-0045
Actively Recruiting
193
Research Site
Fukuoka, Japan, 812-8582
Actively Recruiting
194
Research Site
Fukuoka, Japan, 814-0180
Actively Recruiting
195
Research Site
Hiroshima, Japan, 734-8551
Actively Recruiting
196
Research Site
Kawagoe-shi, Japan, 350-8550
Actively Recruiting
197
Research Site
Kawasaki-shi, Japan, 216-8511
Actively Recruiting
198
Research Site
Kitaadachi-gun, Japan, 362-0806
Actively Recruiting
199
Research Site
Kitakyushu-shi, Japan, 807-8555
Actively Recruiting
200
Research Site
Kobe, Japan, 650-0017
Actively Recruiting
201
Research Site
Kōtoku, Japan, 135-8550
Actively Recruiting
202
Research Site
Kumamoto, Japan, 860-8556
Actively Recruiting
203
Research Site
Kumamoto, Japan, 861-4193
Actively Recruiting
204
Research Site
Kyoto, Japan, 612-8555
Not Yet Recruiting
205
Research Site
Matsusaka-shi, Japan, 515-8544
Actively Recruiting
206
Research Site
Osaka, Japan, 541-8567
Actively Recruiting
207
Research Site
Ota-shi, Japan, 373-8550
Actively Recruiting
208
Research Site
Saitama-shi, Japan, 338-0001
Actively Recruiting
209
Research Site
Sendai, Japan, 981-0914
Actively Recruiting
210
Research Site
Shinjuku-ku, Japan, 160-0023
Actively Recruiting
211
Research Site
Sunto-gun, Japan, 411-8777
Actively Recruiting
212
Research Site
Takaoka-shi, Japan, 933-8555
Actively Recruiting
213
Research Site
Yokohama, Japan, 232-0024
Actively Recruiting
214
Research Site
Yokohama, Japan, 241-8515
Actively Recruiting
215
Research Site
Kuala Lumpur, Malaysia, 59100
Actively Recruiting
216
Research Site
Kuching, Malaysia, 93586
Actively Recruiting
217
Research Site
Petaling Jaya, Malaysia, 47500
Actively Recruiting
218
Research Site
Alkmaar, Netherlands, 1815 JD
Actively Recruiting
219
Research Site
Ede, Netherlands, 6716 RP
Actively Recruiting
220
Research Site
Groningen, Netherlands, 9713 GZ
Withdrawn
221
Research Site
Leidschendam, Netherlands, 2262 BA
Actively Recruiting
222
Research Site
Veldhoven, Netherlands, 5504 DB
Actively Recruiting
223
Research Site
Lima, Peru, 15036
Withdrawn
224
Research Site
Lima, Peru, 15102
Withdrawn
225
Research Site
Lima, Peru, LIMA 29
Withdrawn
226
Research Site
Lima, Peru, Lima 34
Withdrawn
227
Research Site
Bialystok, Poland, 15-027
Withdrawn
228
Research Site
Biała Podlaska, Poland, 21-500
Suspended
229
Research Site
Bydgoszcz, Poland, 85-796
Suspended
230
Research Site
Bystra, Poland, 43-360
Actively Recruiting
231
Research Site
Lodz, Poland, 93-338
Actively Recruiting
232
Research Site
Poznan, Poland, 60-569
Actively Recruiting
233
Research Site
Warsaw, Poland, 04-141
Not Yet Recruiting
234
Research Site
San Juan, Puerto Rico, 00918
Suspended
235
Research Site
San Juan, Puerto Rico, 00935
Actively Recruiting
236
Research Site
Gyeonggi-do, South Korea, 13620
Actively Recruiting
237
Research Site
Seoul, South Korea, 03080
Actively Recruiting
238
Research Site
Seoul, South Korea, 03722
Actively Recruiting
239
Research Site
Seoul, South Korea, 06351
Actively Recruiting
240
Research Site
Seoul, South Korea, 06591
Actively Recruiting
241
Research Site
Seoul, South Korea, 07061
Actively Recruiting
242
Research Site
Songpa-gu, South Korea, 05505
Actively Recruiting
243
Research Site
Barcelona, Spain, 8035
Actively Recruiting
244
Research Site
Castellon, Spain, 12002
Actively Recruiting
245
Research Site
Las Palmas de Gran Canaria, Spain, 35016
Actively Recruiting
246
Research Site
Madrid, Spain, 28034
Actively Recruiting
247
Research Site
Madrid, Spain, 28046
Actively Recruiting
248
Research Site
Majadahonda, Spain, 28222
Actively Recruiting
249
Research Site
Seville, Spain, 41013
Actively Recruiting
250
Research Site
Kaohsiung City, Taiwan, 80756
Actively Recruiting
251
Research Site
Kaohsiung City, Taiwan, 824
Actively Recruiting
252
Research Site
New Taipei City, Taiwan, 220
Actively Recruiting
253
Research Site
New Taipei City, Taiwan, 23561
Actively Recruiting
254
Research Site
Taichung, Taiwan, 40201
Actively Recruiting
255
Research Site
Taichung, Taiwan, 40705
Actively Recruiting
256
Research Site
Tainan, Taiwan, 736
Actively Recruiting
257
Research Site
Taoyuan, Taiwan, 333423
Actively Recruiting
258
Research Site
Bangkok, Thailand, 10700
Actively Recruiting
259
Research Site
Chiang Mai, Thailand, 50200
Actively Recruiting
260
Research Site
Dusit, Thailand, 10300
Actively Recruiting
261
Research Site
Nakhon Ratchasima, Thailand, 30000
Actively Recruiting
262
Research Site
Songkhla, Thailand, 90110
Actively Recruiting
263
Research Site
Ankara, Turkey (Türkiye), 06010
Actively Recruiting
264
Research Site
Antalya, Turkey (Türkiye), 07070
Actively Recruiting
265
Research Site
Antalya, Turkey (Türkiye), 07100
Actively Recruiting
266
Research Site
Edirne, Turkey (Türkiye), 22030
Actively Recruiting
267
Research Site
Izmir, Turkey (Türkiye), 35965
Actively Recruiting
268
Research Site
Seyhan, Turkey (Türkiye), 1060
Actively Recruiting
269
Research Site
Aberdeen, United Kingdom, AB25 2ZN
Actively Recruiting
270
Research Site
Cambridge, United Kingdom, CB2 0QQ
Actively Recruiting
271
Research Site
Edinburgh, United Kingdom, EH4 2XU
Actively Recruiting
272
Research Site
Exeter, United Kingdom, EX2 5DW
Withdrawn
273
Research Site
Greater London, United Kingdom, SW3 6JJ
Actively Recruiting
274
Research Site
London, United Kingdom, EC1A 7BE
Actively Recruiting
275
Research Site
London, United Kingdom, SE1 9RT
Actively Recruiting
276
Research Site
Manchester, United Kingdom, M20 4BX
Actively Recruiting
277
Research Site
Newcastle upon Tyne, United Kingdom, NE7 7AF
Actively Recruiting
278
Research Site
Torquay, United Kingdom, TQ2 7AA
Actively Recruiting
279
Research Site
Can Tho, Vietnam, 900000
Actively Recruiting
280
Research Site
Hanoi, Vietnam, 100000
Actively Recruiting
281
Research Site
Ho Chi Minh City, Vietnam, 700000
Actively Recruiting
282
Research Site
Vinh, Vietnam, 460000
Actively Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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