Actively Recruiting
Global Research Initiative for Patients Screening on MASH
Led by Julius Clinical · Updated on 2024-08-01
10000
Participants Needed
13
Research Sites
404 weeks
Total Duration
On this page
Sponsors
J
Julius Clinical
Lead Sponsor
U
UMC Utrecht
Collaborating Sponsor
AI-Summary
What this Trial Is About
GRIPonMASH will assist (primary) health care providers clinicians to implement the latest patient care pathway, as described by the European Association for the Study of the Liver (EASL), to identify patients at risk of severe metabolic dysfunction-associated steatotic liver disease (MASLD) and to raise awareness. The primary objective is to implement a transmural patient care pathway, in order to identify patients with MASLD and its progressive form metabolic dysfunction-associated steatohepatitis (MASH) in primary care centres and clinics in 10 European countries.
CONDITIONS
Official Title
Global Research Initiative for Patients Screening on MASH
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Newly diagnosed with type 2 diabetes mellitus, metabolic syndrome, obesity, or arterial hypertension according to study definitions
- Currently treated for type 2 diabetes mellitus, metabolic syndrome, obesity, or arterial hypertension with prior diagnosis
- For type 2 diabetes mellitus: fasting glucose > 7.0 mmol/L at least twice, or elevated non-fasting glucose > 11.1 mmol/L 2 hours after OGTT, or HbA1c 48 mmol/mol (6.5%), or active treatment for previously diagnosed type 2 diabetes
- For obesity: body mass index (BMI) > 30, or waist circumference meeting specific thresholds by ethnicity and gender
- For arterial hypertension: systolic BP 140 mmHg and/or diastolic BP 90 mmHg, or active treatment for previously diagnosed hypertension
- For metabolic syndrome: central obesity by waist circumference or BMI > 30, plus at least two of raised triglycerides, reduced HDL cholesterol, raised blood pressure, or raised fasting plasma glucose according to defined thresholds
You will not qualify if you...
- Known hepatitis B, hepatitis C, HIV, or other liver conditions such as hemochromatosis, sarcoidosis, or Wilson's disease
- Known conditions causing liver fibrosis or cirrhosis
- Excessive alcohol use: more than 3 units/day for males or more than 2 units/day for females
- History or evidence of other significant medical conditions or planned procedures that may affect safety or study participation
- Employment or family relationship to study investigators or sponsor personnel
- Inability to understand protocol details or provide written informed consent
- Pregnancy or breastfeeding
- Bariatric surgery within the last 12 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 13 locations
1
Hôpital Erasme, Cliniques Universitaires De Bruxelles
Brussels, Vlaams-brabant, Belgium, B-1070
Actively Recruiting
2
Antwerp University Hospital
Antwerp, Belgium, B-2650
Active, Not Recruiting
3
4th internal clinic General University Hospital
Prague, Bohemia, Czechia, 128 08
Not Yet Recruiting
4
Hôpital de la Pitié Salpêtrière
Paris, Il-de-France, France, 75013
Not Yet Recruiting
5
Universitätsmedizin Mainz
Mainz, Rhineland-Palatinate, Germany, 55131
Actively Recruiting
6
Universitätsklinikum des Saarlandes
Homburg, Saarland, Germany, 66421
Not Yet Recruiting
7
Harokopio University of Athens
Athens, Greece, 17676
Not Yet Recruiting
8
Fondazione Policlinico Universitario Agostino Gemelli IRCCS (FPG), Università Cattolica del Sacro Cuore (UCSC)
Rome, Lazio, Italy, 00168
Not Yet Recruiting
9
Amsterdam UMC
Amsterdam, South Holland, Netherlands, 1105 AZ
Actively Recruiting
10
Franciscus Gasthuis & Vlietland
Rotterdam, South Holland, Netherlands, 3045 PM
Actively Recruiting
11
ULSSM - Unidade Local de Saúde Santa Maria, E.P.E
Lisbon, Portugal, 1649-028
Actively Recruiting
12
Sacele Municipal Hospital
Săcele, Brașov County, Romania, 505600
Not Yet Recruiting
13
Hospital Universitario Virgen del Rocío
Seville, Spain, 41013
Actively Recruiting
Research Team
D
de Jong
CONTACT
W
Wijkhuis
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here