Actively Recruiting
Global SYMPLICITY Registry (GSR) DEFINE
Led by Medtronic Vascular · Updated on 2026-04-27
5000
Participants Needed
2
Research Sites
1034 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective, multi-center, single-arm, non-interventional and open-label registry. The purpose of the registry is to document the long-term safety and effectiveness of renal denervation in a real world patient population with hypertension GSR DEFINE is the continuation of the Global SYMPLICITY Registry and collectively will enroll approximately 5000 patients with hypertension who undergo the renal denervation procedure, from over 300 sites worldwide. Subjects included in GSR DEFINE will be followed for a minimum of 1 year and up to 5 years post-procedure. Patients with uncontrolled hypertension will be enrolled in accordance with the inclusion criteria specified in the protocol.
CONDITIONS
Official Title
Global SYMPLICITY Registry (GSR) DEFINE
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 218 years or minimum age as required by local regulations
- Acceptable candidate for renal denervation based on Medtronic renal denervation system Instructions For Use
- Signed informed consent to participate and allow medical data collection and release
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Universitätsklinikum des Saarlandes
Homburg, Saarlandes, Germany, D-66421
Actively Recruiting
2
Universitätsspital Basel
Basel, Switzerland, Switzerland, 4031
Actively Recruiting
Research Team
K
K. Wandrey
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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