Actively Recruiting
Global Trial in APG2575 for Patients With CLL/SLL
Led by Ascentage Pharma Group Inc. · Updated on 2025-09-18
400
Participants Needed
2
Research Sites
201 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a global multicenter, open label, randomized, registrational phase III study to investigate the efficacy and safety of lisaftoclax in combination with BTK inhibitors in CLL/SLL patients who previously treated with BTK inhibitors
CONDITIONS
Official Title
Global Trial in APG2575 for Patients With CLL/SLL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Documented CLL/SLL meeting iwCLL 2018 criteria and receiving BTKi monotherapy for at least 12 months
- ECOG Performance Status grade 0 to 2
- Adequate bone marrow function with absolute neutrophil count ≥ 1.0 x 10^9/L, platelet counts ≥ 75 x 10^9/L, and hemoglobin ≥ 9 g/dL
- Adequate renal function with creatinine clearance > 50 ml/min or normal creatinine values
- Adequate liver function with total bilirubin ≤ 1.5 x ULN (except Gilbert's Syndrome), AST ≤ 2.5 x ULN, ALT ≤ 2.5 x ULN, and coagulation tests ≤ 1.5 x ULN
- Ability and willingness to provide informed consent and follow study schedule
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
2
Kaluga Regional Clinical Research
Kaluga, Russia, 246007
Actively Recruiting
Research Team
L
Laura Glass
CONTACT
Y
Yifan Zhai, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here