Glofitamab in relapsed/refractory diffuse large B-cell lymphoma: Real-world data.
Elif Birtas Atesoglu, Zafer Gulbas, Ant Uzay...
https://pubmed.ncbi.nlm.nih.gov/37211991/Actively Recruiting
Led by Peking Union Medical College Hospital · Updated on 2026-03-27
20
Participants Needed
1
Research Sites
52 weeks
Total Duration
Researchers are evaluating glofitamab as a single treatment in Chinese patients with relapsed or refractory diffuse large B-cell lymphoma DLBCL who have not responded to at least two previous systemic therapies. The study aims to assess the safety and effectiveness of this drug in managing this type of lymphoma. Participants will receive glofitamab at standard doses as the only treatment during the study. This observational study monitors patients over time without comparing to a placebo or other therapies. The focus is on how well the drug works and its safety in this specific patient group. During the study, researchers will follow patients for at least one year to measure progression-free survival. Additional outcomes include overall survival over two years, complete response rates at 6, 18, and 36 weeks, overall response rates at the same intervals, duration of response over two years, and adverse events over two years. Patients will undergo assessments to track disease status and treatment side effects throughout the study period.
CONDITIONS
Glofitamab in Chinese Patients With R/R DLBCL
J
Jing Ruan
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Peking Union Medical College Hospital
Lead Sponsor
You may qualify if you...
You will not qualify if you...
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration as per treatment protocol until disease progression or discontinuation
Participants receive Glofitamab as a single agent according to standard dosage.
Visits scheduled according to treatment cycles
Duration - Up to 2 years post-treatment
Participants are monitored for progression-free survival, overall survival, response rates, duration of response, and adverse events.
Periodic visits over 2 years
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Lead Sponsor