Management of Challenging Cardiopulmonary Bypass Separation.
Fabrizio Monaco, Ambra Licia Di Prima, Jun Hyun Kim...
https://pubmed.ncbi.nlm.nih.gov/32276758Actively Recruiting
Age: 18Years +
All Genders
ID07390903
Global Longitudinal Strain as a Predictor of Difficult Separation From Cardiopulmonary Bypass in Adults Undergoing Elective Cardiac Surgery
Led by Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital · Updated on 2026-02-05
213
Participants Needed
2
Research Sites
4 weeks
Total Duration
On this page
Sponsors
K
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Lead Sponsor
U
University of Rome Tor Vergata
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating whether global longitudinal strain (GLS), measured by echocardiography, can predict difficulties when separating from cardiopulmonary bypass (CPB) in adults undergoing planned heart surgery. The study aims to determine if preoperative GLS can forecast the need for multiple heart support drugs during CPB weaning and how GLS values relate to outcomes like ICU stay, hospital stay, heart-related lab results, and survival within 30 days. This observational study addresses a gap in understanding early heart function changes during surgery.
CONDITIONS
Brief Title
GLS in Difficult CPB Weaning
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Age over 18 years
- Scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB)
- Provided written informed consent to participate
- Eligible surgeries include isolated mitral valve replacement or repair
- Eligible surgeries include isolated aortic valve replacement or repair
- Eligible surgeries include isolated coronary artery bypass grafting (CABG)
- Eligible surgeries include combined valve and CABG surgery
- Eligible surgeries include multiple valve replacement or repair
- Eligible surgeries include surgery involving ascending aorta or aortic arch
You will not qualify if you...
- Emergency cardiac surgery
- Redo cardiac surgery
- Contraindications to transesophageal echocardiography (TEE)
- Ongoing inotropic drug therapy
- Preoperative mechanical circulatory support such as IABP, ECMO, or VAD
- Requirement for mechanical ventilation before surgery
- Preoperative atrial fibrillation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Day of surgery
Participants undergo echocardiographic assessments to measure myocardial function using global longitudinal strain (GLS) before, during, and after cardiac surgery.
1 perioperative day with multiple echocardiography assessments
Long-term Monitoring
Duration - 30 days after surgery
Participants are monitored after surgery for postoperative outcomes including ICU and hospital length of stay, cardiac biomarker trajectories, and survival up to 30 days.
Follow-up visits as per standard postoperative care within 30 days
Trial Site Locations
Total: 2 locations
1
University of Rome Tor Vergata
Rome, Italy
Actively Recruiting
2
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Istanbul, Turkey (Türkiye)
Actively Recruiting
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Research Team
M
Mustafa E Gurcu, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Published Research Related To This Trial
Strain Imaging: An Everyday Tool for the Perioperative Echocardiographer.
Michael J Benson, Natalie Silverton, Candice Morrissey...
https://pubmed.ncbi.nlm.nih.gov/31919005Reduced Left Ventricular Global Longitudinal Strain Predicts Prolonged Hospitalization: A Cohort Analysis of Patients Having Aortic Valve Replacement Surgery.
Abraham Sonny, Andrej Alfirevic, Shiva Sale...
https://pubmed.ncbi.nlm.nih.gov/29200066Operative mortality in adult cardiac surgery: is the currently utilized definition justified?
Patrick G Chan, Laura Seese, Edgar Aranda-Michel...
https://pubmed.ncbi.nlm.nih.gov/34795909Difficult and complex separation from cardiopulmonary bypass in high-risk cardiac surgical patients: a multicenter study.
André Y Denault, Jean-Claude Tardif, C David Mazer...
https://pubmed.ncbi.nlm.nih.gov/22578975