Actively Recruiting
GLS in Difficult CPB Weaning
Led by Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital · Updated on 2026-02-05
213
Participants Needed
2
Research Sites
29 weeks
Total Duration
On this page
Sponsors
K
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Lead Sponsor
U
University of Rome Tor Vergata
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to learn whether global longitudinal strain (GLS), measured by echocardiography, can predict difficulty separating from cardiopulmonary bypass (CPB) in adults undergoing elective cardiac surgery. The main questions it aims to answer are: * Can preoperative GLS measurement predict difficult separation from CPB? * Are GLS values associated with outcomes such as intensive care unit (ICU) stay, hospital stay, cardiac biomarkers, or 30-day mortality? Participants will: * Undergo standard cardiac surgery requiring CPB * Have echocardiographic assessments (TTE before and after surgery) * Have their recovery and outcomes monitored, including ICU and hospital stay, postoperative labs, and survival within 30 days
CONDITIONS
Official Title
GLS in Difficult CPB Weaning
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years
- Scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB)
- Provided written informed consent to participate
- Eligible surgical procedures include isolated mitral valve replacement or repair
- Eligible surgical procedures include isolated aortic valve replacement or repair
- Eligible surgical procedures include isolated coronary artery bypass grafting (CABG)
- Eligible surgical procedures include combined valve and CABG surgery
- Eligible surgical procedures include multiple valve replacement or repair
- Eligible surgical procedures include surgery involving the ascending aorta or aortic arch
You will not qualify if you...
- Emergency cardiac surgery
- Redo cardiac surgery
- Contraindications to transesophageal echocardiography (TEE)
- Critical preoperative conditions including ongoing inotropic drug therapy
- Critical preoperative conditions including preoperative mechanical circulatory support such as IABP, ECMO, or VAD
- Critical preoperative conditions including requirement for mechanical ventilation
- Critical preoperative conditions including preoperative atrial fibrillation
AI-Screening
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Trial Site Locations
Total: 2 locations
1
University of Rome Tor Vergata
Rome, Italy
Actively Recruiting
2
Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
M
Mustafa E Gurcu, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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