What is this study trying to find out about cardiopulmonary bypass complications?

This study aims to learn if global longitudinal strain (GLS), a heart function measurement using echocardiography, can predict difficulty when separating from cardiopulmonary bypass during planned heart surgery. Researchers want to understand if GLS relates to outcomes like ICU stay, hospital stay, heart lab results, and survival within 30 days. The study is sponsored by Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital.

Who may be eligible for this cardiopulmonary bypass clinical trial?

Adults aged 18 years or older scheduled for elective cardiac surgery needing cardiopulmonary bypass may be eligible. Both men and women can join unless they have emergency or repeat heart surgery, contraindications to certain heart scans, or critical heart conditions like mechanical support or atrial fibrillation. Please review eligibility criteria for more details.

Is there any cost to participate in this cardiopulmonary bypass clinical trial?

Study-related care, including the heart scans and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered. Participants should plan accordingly.

Actively Recruiting

Age: 18Years +

All Genders

ID07390903

Using Global Longitudinal Strain to Predict Difficulty Separating From Cardiopulmonary Bypass in Adults Undergoing Elective Cardiac Surgery

Led by Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital · Updated on 2026-02-05

213

Participants Needed

Research Sites

4 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are investigating whether global longitudinal strain GLS, measured by echocardiography, can predict difficulties when separating from cardiopulmonary bypass CPB in adults undergoing planned heart surgery. The study aims to determine if preoperative GLS can forecast the need for multiple heart support drugs during CPB weaning and how GLS values relate to outcomes like ICU stay, hospital stay, heart-related lab results, and survival within 30 days. This observational study addresses a gap in understanding early heart function changes during surgery.

CONDITIONS

Brief Title

GLS in Difficult CPB Weaning

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Age over 18 years
Scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB)
Provided written informed consent to participate
Eligible surgeries include isolated mitral valve replacement or repair
Eligible surgeries include isolated aortic valve replacement or repair
Eligible surgeries include isolated coronary artery bypass grafting (CABG)
Eligible surgeries include combined valve and CABG surgery
Eligible surgeries include multiple valve replacement or repair
Eligible surgeries include surgery involving ascending aorta or aortic arch

You will not qualify if you...

Emergency cardiac surgery
Redo cardiac surgery
Contraindications to transesophageal echocardiography (TEE)
Ongoing inotropic drug therapy
Preoperative mechanical circulatory support such as IABP, ECMO, or VAD
Requirement for mechanical ventilation before surgery
Preoperative atrial fibrillation

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Day of surgery

Participants undergo echocardiographic assessments to measure myocardial function using global longitudinal strain (GLS) before, during, and after cardiac surgery.

1 perioperative day with multiple echocardiography assessments

Long-term Monitoring

Duration - 30 days after surgery

Participants are monitored after surgery for postoperative outcomes including ICU and hospital length of stay, cardiac biomarker trajectories, and survival up to 30 days.

Follow-up visits as per standard postoperative care within 30 days