Actively Recruiting
Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
Led by The University of Texas Health Science Center at San Antonio · Updated on 2025-09-09
80
Participants Needed
2
Research Sites
1134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overall goal of this project is to understand the mechanisms by which gastric bypass surgery improves glucose metabolism. The central hypothesis guiding this project is that the reconfiguration of intestinal transit with the Roux-en-Y will increase the release of insulinotropic GI hormones, termed incretins that improve insulin secretion and glucose metabolism. The study is divided into three specific aims. 1. To determine the role of incretin hormones on insulin secretion in patients with gastric bypass surgery using intravenous-oral hyperglycemic clamp. 2. To compare incretin effect and glucose tolerance among patient who suffer from hypoglycemia after RYGB and asymptomatic surgical and non-surgical individuals. 3. To quantify the contribution of GLP-1 to incretin effect enhancement following surgery.
CONDITIONS
Official Title
Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 65 years
- Healthy individuals without diabetes or active organ disease
- Individuals who have had bariatric surgery
- Experiencing recurrent hypoglycemia after gastric bypass surgery
You will not qualify if you...
- Pregnancy
- Significant anemia
- Current diabetes unless preparing for bariatric surgery
- Gastrointestinal obstruction
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Texas Diabetes Institute - University Health System
San Antonio, Texas, United States, 78207
Actively Recruiting
2
South Texas Veterans Health Care System
San Antonio, Texas, United States, 78229
Actively Recruiting
Research Team
M
Marzieh Salehi, MD MS
CONTACT
J
Jennifer Foster, MSN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
FACTORIAL
Primary Purpose
OTHER
Number of Arms
2
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