Actively Recruiting
The Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Healthy Individuals
Led by University Hospital, Gentofte, Copenhagen · Updated on 2024-05-17
10
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study is a randomised, double-blinded, placebo-controlled, crossover study enrolling 10 healthy male participants. Each participant will undergo four separate study days in randomised order. Each study day encompasses a continous 90-minute i.v. infusion with either placebo, glucose-dependent insulinotropic polypeptide (GIP), alanine or GIP + alanine. The primary objective of the study is to find out whether intravenous administration of the naturally occuring gut hormone GIP and the amino acid alanine, separately and combined, results in additive or synergistic glucagonotropic effects during euglycaemic conditions in healthy participants. Secondary objectives are to disclose the effect of the abovementioned interventions on insulin secretion and circulating levels of total and individual amino acids.
CONDITIONS
Official Title
The Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Healthy Individuals
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Caucasian ethnicity
- Body mass index (BMI) 20-27 kg/m^2
- Glycated haemoglobin (HbA1c) ≤ 42 mmol/mol
- Informed and written consent
You will not qualify if you...
- Late microvascular complications except mild nonproliferative retinopathy
- Liver disease (alanine aminotransferase (ALAT) and/or aspartate aminotransferase (ASAT) > 2 times normal values) or history of hepatobiliary disorder
- Treatment with any glucose-lowering drugs
- Active or recent (within 5 years) malignant disease
- Active tobacco smoking/use
- Any condition considered incompatible with participation by the investigators.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Center for Clinical Metabolic Research, Gentofte Hospital
Hellerup, Capital Region, Denmark, 2900
Actively Recruiting
Research Team
J
Julie V Warnøe, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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