Actively Recruiting
The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers
Led by University of Miami · Updated on 2026-03-04
20
Participants Needed
1
Research Sites
61 weeks
Total Duration
On this page
Sponsors
U
University of Miami
Lead Sponsor
E
Exegi Pharma
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this pilot study is to explore a combination of two interventions: (1) a behavioral alcohol-reduction intervention using motivational interviewing, and (2) a blinded probiotic microbiome or placebo intervention. The study examines whether these interventions improve cognitive and neurophysiological function, including brain metabolism, in older adults who are high-risk alcohol drinkers.
CONDITIONS
Official Title
The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Between 65 and 84 years of age
- English speaking
- Able to provide valid informed consent, understand study requirements, risks, and benefits, and comply with the protocol
- Heavy drinker defined as >14 alcoholic drinks/week for men and >7 drinks/week for women
- Interested in reducing their alcohol consumption
You will not qualify if you...
- Body Mass Index (BMI) of 35 or higher
- Fasting glucose greater than 125 mg/dL
- Current or previous diagnosis of Type 1 or Type 2 Diabetes
- Requires use of insulin or other glucose-lowering agents
- Unable to fast for 12 hours
- Past serious alcohol withdrawal symptoms
- Contraindications for MRI (e.g., certain devices, implants, claustrophobia)
- Diagnosed with a neurodegenerative disease such as Alzheimer's Disease
- Diagnosed with a psychotic disorder
- Current substance dependence diagnosis except mild or moderate alcohol use
- Consumed over 300 alcoholic drinks in the past 30 days
- Current or recent probiotic use within the past 30 days
- Current or recent antibiotic use within the past 30 days
- In active cancer treatment or have advanced cancer
- Taking daily steroids or immunosuppressants
- History of organ or bone marrow transplant, primary immunodeficiency, or prescribed immunosuppressant medications
- Exclusion at the principal investigator's discretion
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Miami
Miami, Florida, United States, 33136
Actively Recruiting
Research Team
T
Teddy Salan, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
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