Actively Recruiting
Glucocorticoids Versus Placebo for the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Led by Fondation Hôpital Saint-Joseph · Updated on 2026-03-02
110
Participants Needed
29
Research Sites
166 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is associated with a poor prognosis, with a 3-month mortality rate of over 50%. To date, no treatment has been proven to be effective in AI-FPI. The interest of glucocorticoids is controversial and needs to be confirmed. This confirmation is mandatory to validate the improvement of the prognosis of EA-IPF under this treatment but also to search for unsuspected deleterious effects as it has been shown with immunosuppressants in stable idiopathic pulmonary fibrosis.
CONDITIONS
Official Title
Glucocorticoids Versus Placebo for the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient is 18 years of age or older
- Diagnosis of IPF or likely IPF based on 2018 international recommendations
- Definite or suspected acute exacerbation of IPF defined by international criteria, including acute worsening of breathing within less than 1 month, new bilateral lung abnormalities on CT, and exclusion of other causes
- For women of childbearing age, use of effective contraception during the study
- Affiliated to social security
- Ability to understand and sign informed consent or having a relative who can consent if patient is incapacitated
You will not qualify if you...
- Identified cause for acute worsening such as infection
- Known allergy to glucocorticoids or study treatment components
- Need for or current use of mechanical ventilation
- Active bacterial, viral, fungal, or parasitic infection (specific viruses like SARS-CoV-2, Influenza A/B, and RSV considered active viral infection)
- Active cancer
- On lung transplant waiting list
- Treatment with glucocorticoids over 1 mg/kg/day for more than 7 days within the last 15 days
- Participation in another interventional clinical trial
- Pregnancy or breastfeeding
- Under tutorship, curatorship, court protection, or deprived of liberty
AI-Screening
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Trial Site Locations
Total: 29 locations
1
CHU ANgers
Angers, France
Actively Recruiting
2
CHU de Besancon
Besançon, France
Actively Recruiting
3
Hôpital Avicenne
Bobigny, France
Not Yet Recruiting
4
CHU BOrdeaux
Bordeaux, France
Actively Recruiting
5
CHU Caen
Caen, France
Actively Recruiting
6
CHU Clermont-Ferrand
Clermont-Ferrand, France
Not Yet Recruiting
7
CHIC
Créteil, France
Actively Recruiting
8
CHU de Dijon
Dijon, France
Actively Recruiting
9
CHU Grenoble
Grenoble, France
Not Yet Recruiting
10
CHRU Lille
Lille, France
Not Yet Recruiting
11
Hospices Civils de Lyon
Lyon, France
Actively Recruiting
12
Hôpital Nord
Marseille, France
Actively Recruiting
13
CHU de Montpellier
Montpellier, France
Not Yet Recruiting
14
CHU Nancy
Nancy, France
Actively Recruiting
15
CHU de Nantes
Nantes, France
Not Yet Recruiting
16
CHU Nice
Nice, France
Not Yet Recruiting
17
Hôpital Paris Saint-Joseph
Paris, France, 75014
Actively Recruiting
18
Hôpital Bichat
Paris, France
Actively Recruiting
19
Hôpital Européen Georges Pompidou
Paris, France
Actively Recruiting
20
Hôpital FOCH
Paris, France
Not Yet Recruiting
21
Hôpital Kremiln Bicetre
Paris, France
Actively Recruiting
22
Hôpital Saint-Louis
Paris, France
Not Yet Recruiting
23
Hôpital Tenon
Paris, France
Actively Recruiting
24
CHU Reims
Reims, France
Actively Recruiting
25
CHU Rennes
Rennes, France
Actively Recruiting
26
CHU Rouen
Rouen, France
Not Yet Recruiting
27
CHU Strasbourg
Strasbourg, France
Not Yet Recruiting
28
CHU Toulouse
Toulouse, France
Actively Recruiting
29
CHU Tours
Tours, France
Not Yet Recruiting
Research Team
J
Jean-Marc NACCACHE, MD
CONTACT
H
Helene BEAUSSIER, PharmD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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