Actively Recruiting

Phase 2
Age: 18Years - 74Years
All Genders
NCT06976658

Glucokinase Activator in Monogenic Diabetes

Led by Chinese University of Hong Kong · Updated on 2026-04-30

44

Participants Needed

1

Research Sites

87 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Evaluating a novel, allosteric glucokinase activator in monogenic diabetes secondary to inactivating glucokinase mutations: a randomised, cross-over trial

CONDITIONS

Official Title

Glucokinase Activator in Monogenic Diabetes

Who Can Participate

Age: 18Years - 74Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Age 18 years or older and less than 75 years
  • Body mass index (BMI) greater than 18 and less than 30 kg/m2
  • Fasting plasma glucose greater than 5.6 mmol/L at screening
  • Confirmed heterozygous carrier of a pathogenic or likely pathogenic glucokinase (GCK) mutation based on established genetic guidelines
Not Eligible

You will not qualify if you...

  • Body weight less than 45 kg at screening
  • Current or planning pregnancy or lactating
  • Stroke or cardiovascular disease within 6 months before recruitment
  • Severe kidney dysfunction (estimated glomerular filtration rate less than 30 mL/min/1.73 m2 or on renal replacement therapy)
  • Severe liver dysfunction (liver enzymes more than 3 times the upper limit of normal)
  • History of drug abuse or excessive alcohol use
  • Severe low blood sugar episodes within 6 months before screening
  • Anemia with hemoglobin less than 10 g/dL at screening
  • Excessive blood loss over 300 mL within 1 month before screening
  • Use of strong or moderate CYP3A4 inhibitors or inducers
  • Use of certain diabetes medications (sulfonylureas, DPP-4 inhibitors, GLP-1 agonists, SGLT2 inhibitors, insulin, thiazolidinediones, acarbose) within 6 weeks before randomization
  • Use of long-term high-dose corticosteroids at randomization
  • Serious infections at the time of screening

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

3M, Diabetes and Endocrine Research Center

Hong Kong, Hong Kong

Actively Recruiting

Loading map...

Research Team

E

Elaine Chow, MD

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

CROSSOVER

Primary Purpose

TREATMENT

Number of Arms

2

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here