Actively Recruiting
Glucose Consumption During Deep Brain Stimulation With Functional [18F]FDG-Brain-PET in Obsessive-Compulsive Disorder
Led by Medical University of Vienna · Updated on 2025-06-13
8
Participants Needed
1
Research Sites
230 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this randomized, sham-controlled study is to evaluate the effectiveness of DBS therapy in individuals suffering from severe OCD and to investigate DBS treatment with functional \[18F\]FDG-Brain-PET.
CONDITIONS
Official Title
Glucose Consumption During Deep Brain Stimulation With Functional [18F]FDG-Brain-PET in Obsessive-Compulsive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- A score of 25 or higher on the Yale-Brown Obsessive Compulsive Scale
- Previous failure to respond to at least two medication trials with serotonin reuptake inhibitors at or beyond FDA maximum recommended dose for at least ten weeks each
- At least one trial with tricyclic medication at or beyond FDA maximum recommended dose for at least ten weeks
- At least one trial of augmentation with antipsychotic medication, lithium, a benzodiazepine, or buspirone
- At least one trial of psychotherapy (cognitive behavioral therapy or comparable techniques) for at least 20 sessions
- Ability to provide written informed consent
You will not qualify if you...
- Any history of current or past psychotic disorder
- A manic episode within the preceding three years
- Any current clinically significant medical or neurological disorder contraindicating DBS
- Any disease leading to altered glucose reactivity (e.g., diabetes)
- Any clinically significant preoperative MRI abnormality or inability to undergo presurgical MRI
- Current or unstable remitted substance abuse or dependence except nicotine
- Pregnancy or high risk of becoming pregnant during study and refusal to use proper contraception
- Any current severe personality disorder except comorbid anankastic personality disorder
- Inability to follow the study protocol or adhere to operational requirements
- Current and unstable suicidality
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Medical University of Vienna, Department of Psychiatry and Psychotherapy
Vienna, State of Vienna, Austria, 1090
Actively Recruiting
Research Team
C
Christoph Kraus, MD PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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