Actively Recruiting
Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
Led by Baylor College of Medicine · Updated on 2025-06-10
52
Participants Needed
1
Research Sites
254 weeks
Total Duration
On this page
Sponsors
B
Baylor College of Medicine
Lead Sponsor
T
The Methodist Hospital Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
Alzheimer's disease (AD) is associated with significant, progressive cognitive decline. Key defects in mitochondrial fuel metabolism insulin resistance, inflammation and decreased brain glucose uptake are linked to AD. This trial will investigate the effects of supplementing glycine and N-acetylcysteine vs. alanine as placebo on these defects in AD, and examine the effects on cognition.
CONDITIONS
Official Title
Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 55-85 years
- Gradual and progressive memory loss for more than 1 year with a Montreal Cognitive Assessment score of 10-20
- Amyloid positivity on PET scan
- Availability of a study partner
You will not qualify if you...
- Hospitalization in past 3 months
- Use of insulin medications
- Untreated thyroid disease
- Creatinine levels greater than 1.5 mg/dL
- Hemoglobin concentration less than 11.0 g/dL
- Known liver disease or AST/ALT level greater than 2 times upper limit of normal
- History of stroke, brain tumor, active heart failure, or active cancer (except removable basal cell cancers)
- Untreated depression or other severe psychiatric disorders
- Pregnancy or nursing (unlikely in this population)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
R
Rajagopal V Sekhar, M.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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