Study on Replacing Table Sugar with Fresh Mango in High and Low Glycemic Breakfasts to Measure Blood Sugar and Insulin Responses

What this Trial Is About

Researchers are investigating how replacing table sugar with fresh mango sugar affects blood sugar, insulin, and vascular health after eating breakfast. The study focuses on adults with a body mass index BMI between 18.5 and 35.0 and explores the impact of sugar type in realistic meals on metabolic and vascular responses, which are important for diabetes and heart disease risk. Participants will take part in four meal trials in a randomized order, consuming breakfasts that are either high or low glycemic and sweetened with fresh mango or table sugar. The meals include corn flakes with 2% milk or steel cut oats with water, with sugar content and calories closely matched. Each trial involves blood sampling and artery dilation measurements before and after the meal, along with surveys on meal acceptability and satiety. Throughout the study, participants will have blood samples taken at multiple times up to three hours after eating to measure glucose, insulin, triglycerides, and HDL cholesterol. Artery dilation will be assessed at various times post-meal using flow-mediated dilation. Additional assessments include a one-time body composition and bone density scan. The study continues for up to 1.5 years to evaluate these effects comprehensively.

Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.