Actively Recruiting
Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.
Led by Ball State University · Updated on 2025-07-01
24
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
Sponsors
B
Ball State University
Lead Sponsor
N
National Mango Board
Collaborating Sponsor
AI-Summary
What this Trial Is About
Large blood sugar and insulin increases after meals high in table sugar are related to risk for diabetes and heart disease. Additionally, large increases in blood sugar may also negatively impact vascular health. Previous research suggests that mango consumed in small quantities has blood sugar-lowering properties, but the evidence of this within larger, more realistic meals is limited. The investigators want to understand if replacing table sugar (sucrose) with sugar from fresh mango (which also contains fiber and plant bioactives) will lead to more favorable blood sugar, insulin, and vascular responses after eating breakfast meals. The investigators will compare the postprandial glycemic, insulinemic, and vascular response to low and high glycemic meals sweetened with either fresh mango or sucrose.
CONDITIONS
Official Title
Glycemic/Insulinemic Effects of Fresh Mango as a Sugar Substitute in Realistic Breakfasts.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 45 years
- Body mass index between 18.5 and 35.0 kg/m2
- Not pregnant (for females)
- Not postmenopausal (for females)
- No diagnosis of cardiovascular disease
- No diagnosis of cardiometabolic conditions such as type 2 diabetes
- No diagnosis of chronic inflammatory conditions like rheumatoid arthritis or inflammatory bowel disease
- Do not regularly take anti-inflammatory drugs more than twice a week
- Do not use glucose-lowering drugs such as metformin
- Do not use lipid-lowering drugs such as statins
- Do not use tobacco products or illicit drugs
- Do not have a pacemaker
- Able to consume mango, wheat, gluten, and milk
- Able to lie in a supine position in the dark for at least ten minutes
You will not qualify if you...
- Younger than 18 or older than 45 years
- Body mass index less than 18.5 or greater than 35.0 kg/m2
- Pregnant (for females)
- Postmenopausal status (for females)
- Diagnosed with cardiovascular disease
- Diagnosed with cardiometabolic conditions such as type 2 diabetes
- Diagnosed with chronic inflammatory conditions like rheumatoid arthritis or inflammatory bowel disease
- Regularly take anti-inflammatory drugs more than twice a week
- Use glucose-lowering drugs such as metformin
- Use lipid-lowering drugs such as statins
- Use tobacco products or illicit drugs
- Have a pacemaker
- Allergic to mango, wheat, gluten, or milk
- Unable to lie in a supine position in the dark for at least ten minutes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Health Professions Building, Ball State University
Muncie, Indiana, United States, 47306
Actively Recruiting
Research Team
B
Bryant Keirns, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
4
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