What is this study trying to find out about chronic kidney disease?

This study aims to understand how the endothelial glycocalyx (eGC) affects small blood vessel function in people with chronic kidney disease (CKD). Researchers compare patients with CKD, hypertension without kidney damage, and healthy volunteers to explore blood vessel health and related markers. The study is led by Josip Juraj Strossmayer University of Osijek to improve scientific knowledge in this area.

Who may be eligible for this chronic kidney disease clinical trial?

Adults aged 18 years or older who have CKD caused by high blood pressure, or high blood pressure without kidney damage, or are healthy volunteers may be eligible. Participants must be non-smokers and not have diabetes. Please review eligibility criteria for more details.

Is there any cost to participate in this chronic kidney disease clinical trial?

Study-related care, including all tests and procedures, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered. Participants can expect to attend a single visit for assessments and sample collection.

Actively Recruiting

Age: 18Years +

All Genders

Healthy Volunteers

ID07437729

The Role of Glycocalyx and Oxidative Stress in Endothelial Function Part 1

Led by Josip Juraj Strossmayer University of Osijek · Updated on 2026-03-02

105

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

This research aims to understand the role of the endothelial glycocalyx eGC in the impaired microvascular function seen in people with chronic kidney disease CKD. The study compares patients with CKD, patients with hypertension but no kidney damage, and healthy volunteers to explore how eGC and related markers affect blood vessel function. It also seeks to enhance scientific collaboration and resources at MEFOS to improve research quality. Participants include three groups those with CKD caused by hypertension at stages 1-2 and 3-5 non-diabetic, non-smokers, patients with hypertension but normal kidney function non-diabetic, non-smokers, and healthy volunteers serving as controls. The study measures microvascular reactivity using a laser Doppler flow meter and assesses eGC thickness with a device called Glycocheck. Blood samples are collected to analyze soluble markers of eGC, oxidative stress, inflammation, and antioxidant capacity. Participants will have one visit where these measurements and blood samples are taken. Researchers will evaluate microvascular reactivity and eGC thickness at baseline, along with various blood markers related to oxidative stress and immune cell frequency. The study results aim to provide insight into endothelial dysfunction in CKD and identify new biomarkers. The total participation time involves this single laboratory visit for assessment and sample collection.

CONDITIONS

Brief Title

Glycocalyx and Oxidative Stress in Endothelial Function (Part 1)

Who Can Participate

Age: 18Years +

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Adults with chronic kidney disease caused by high blood pressure, stages 1-2 and 3-5, with eGFR at least 90 ml/min/1.73 m2 or below 60 ml/min/1.73 m2, who are non-diabetic and non-smokers
Adults with hypertension as defined by ESH2023 Guidelines without kidney damage (eGFR above 90 ml/min/1.73 m2), who are non-diabetic and non-smokers
Healthy volunteer subjects without these conditions

You will not qualify if you...

Kidney disease caused by any reason other than hypertension
Endocrine, autoimmune, or inflammatory diseases that may affect kidney function
Smoking
Diabetes

Research Team

Ines Drenjančević, MD, PhD

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