Actively Recruiting
GLYLO Supplement Pilot Trial on Glycation and Aging in Postmenopausal Women
Led by Buck Institute for Research on Aging · Updated on 2025-09-08
30
Participants Needed
1
Research Sites
65 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this study is to assess the effectiveness of GLYLO, a dietary supplement, in postmenopausal women aged 45 to 65 who are overweight or obese and have elevated HbA1c levels. Specifically, the study seeks to evaluate whether GLYLO can reduce advanced glycation end products (AGEs) levels, which are harmful compounds formed when sugar attaches to proteins or fats in the body and can contribute to aging and disease. The primary outcome of the study is to determine if GLYLO reduces AGEs, enhances metabolic and hormonal health, and mitigates age-related functional decline. This study includes one screening visit and three testing visits over a 6-month period. After eligibility is confirmed, participants will be randomly assigned to one of two groups to take either GLYLO (two capsules daily) or a placebo at home for 24 weeks. Participants will provide blood samples at every visit. During the three testing visits, they will complete physical performance and cognitive function tests, provide both blood and urine samples, and fill out quality of life and 24-hour dietary intake questionnaires. The dietary intake questionnaires will be completed only twice i.e. at the baseline visit and again at the final 6-month visit.
CONDITIONS
Official Title
GLYLO Supplement Pilot Trial on Glycation and Aging in Postmenopausal Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults identified as female at birth with ovaries present
- Postmenopausal for more than 1 year since last menstrual period
- Age between 45 and 65 years
- BMI 25 kg/m2 or higher, or waist circumference 88 cm or greater
- HbA1c between 5.5% and 6.4% at screening
- Able to read and speak English well enough to provide informed consent and understand instructions
- Able to attend in-person visits at The Buck Institute
You will not qualify if you...
- Surgical menopause
- Hysterectomy and/or ovariectomy
- Receiving systemic hormone replacement therapy (local vaginal estrogen therapy allowed)
- Use of weight loss medications in the past 6 months or enrollment in a weight loss program; weight must be stable within 4% over the past 3 months
- Regular use of GLYLO or supplements containing its ingredients in the past 3 months
- Diabetes (type 1 or 2), use of hypoglycemic agents, or fasting glucose above 125 mg/dL
- Elevated blood pressure: systolic ≥180 mmHg or diastolic ≥100 mmHg
- Use of psychotropic or other medications affecting weight unless stable for 6 months
- Liver enzyme levels more than twice the upper limit of normal
- Immunosuppressive disorders or medications including prednisone >10 mg/day or chemotherapy
- Active gastrointestinal bleeding or bleeding disorders within 6 months
- Active peptic ulcer disease within 6 months
- Active malignancy within 6 months except treated non-melanoma skin cancer
- Active infection within 1 month
- Allergy or hypersensitivity to supplement components
- History of hyperthyroidism or thyroid cancer, or abnormal thyroid function
- Unable to provide informed consent or safely complete the study
- Psychiatric conditions affecting protocol compliance
- Active eating disorders
- Active diagnosis of gout
- Changes to prescription medications within 3 months affecting study results
- Overnight hospitalization within 1 month
- Any condition compromising safety or data quality in investigator opinion
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Trial Site Locations
Total: 1 location
1
The Buck Institute for Research on Aging
Novato, California, United States, 94945
Actively Recruiting
Research Team
B
Brianna Stubbs, DPhil
CONTACT
V
Vineeta Tanwar, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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