Actively Recruiting
Gonadotrophin Releasing Hormone Agonist for Dual Trigger in IVF and for Luteal Phase Support in Frozen-thawed Embryo Transfer
Led by The University of Hong Kong · Updated on 2026-05-15
784
Participants Needed
1
Research Sites
90 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are comparing two methods to improve live birth rates in women undergoing IVF and frozen embryo transfer (FET). The study evaluates the use of a dual trigger (GnRH agonist plus hCG) versus hCG alone for IVF, and GnRH agonist versus placebo for luteal phase support in FET. This is a randomized, double-blinded, placebo-controlled Phase 3 trial focusing on women with subfertility. Women undergoing IVF will receive ovarian stimulation and monitoring before being randomly assigned to receive either the dual trigger (recombinant hCG with decapeptyl) or hCG with saline injection. Egg retrieval follows 36 hours later, with embryo transfer occurring 2 or 5 days afterward. In the FET group, women will be randomized to receive either decapeptyl or saline on the day of embryo transfer, with embryos transferred 3 or 6 days after the LH surge. Both groups receive standard embryo culture and transfer protocols. Participants will have pregnancy tests 18 days after treatment, followed by ultrasounds to confirm pregnancy and fetal viability. Data on pregnancy outcomes, including delivery details and complications, will be collected from hospital records or private obstetricians. The study closely tracks live birth rates and other pregnancy outcomes, with follow-up continuing through delivery and neonatal assessments.
CONDITIONS
Brief Title
GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged under 43 years at the time of IVF treatment
- Women replacing early cleavage embryos or blastocysts after thawing in frozen embryo transfer
- Frozen embryo transfer performed in natural cycles
You will not qualify if you...
- Use of preimplantation genetic diagnosis treatment
- Use of donor oocytes or donor embryos
- Presence of hydrosalpinx on pelvic scanning that has not been surgically treated
- Women at risk of ovarian hyperstimulation syndrome (OHSS)
- Frozen early cleavage embryos thawed and cultured to blastocysts before transfer as requested by the patient in frozen embryo transfer cycles
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to ovarian stimulation cycle length plus embryo transfer and 2 weeks of luteal phase support for IVF; FET cycle length up to embryo transfer day
Participants undergoing IVF receive ovarian stimulation, followed by a dual trigger or hCG trigger injection when follicles reach 18 mm, then egg retrieval and embryo transfer. Participants undergoing frozen embryo transfer (FET) receive an injection on the day of transfer after ovulation detection, followed by embryo transfer.
Multiple visits for ovarian stimulation monitoring and 1 to 2 visits for embryo transfer procedures
Duration - Up to delivery (approximately 40 weeks from embryo transfer)
Participants have a pregnancy test about 18 days after the trigger or LH surge. If pregnant, ultrasound is performed 2 weeks later to confirm viability, with ongoing monitoring up to delivery.
1 visit for pregnancy test, 1 ultrasound visit 2 weeks later, plus routine antenatal visits if pregnancy confirmed
Trial Site Locations
Total: 1 location
1
Department of Obstetrics and Gynaecology
Hong Kong, Hong Kong, China
Actively Recruiting
Research Team
E
Ernest HY Ng, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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