Actively Recruiting
Goal-directed LCVP Based on HP in Laparoscopic Hepatectomy
Led by The First Affiliated Hospital with Nanjing Medical University · Updated on 2024-11-12
100
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn about goal-directed LCVP based on hypovolemic phlebotomy (HP) in laparoscopic hepatectomy. The main questions it aims to answer are: 1. The safety and feasibility of HP 2. To evaluate whether HP can reduce perioperative blood transfusion ratio Participants undergoing liver resection with HP was performed by the anesthesiologist. Blood was withdrawn approximately 30 min prior to the initiation of liver parenchymal transection from central venous. The aim was to maintain the CVP between 0 to 5 cmH2O. HP volume was 5-10 mL/kg of patient body weight, generally. Participants in control group undergoing liver resection without HP.
CONDITIONS
Official Title
Goal-directed LCVP Based on HP in Laparoscopic Hepatectomy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of Hepatocellular Carcinoma
- Preference for laparoscopic hepatectomy and patient agreement
You will not qualify if you...
- Age less than 18 years
- Pregnancy
- Refusal of blood product transfusion
- Active cardiac conditions including unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease, or history of congestive heart failure
- History of significant cerebrovascular disease
- Restrictive or obstructive pulmonary disease
- Uncontrolled hypertension
- Renal dysfunction with glomerular filtration rate less than 60 mL/min
- Hemoglobin less than 100 g/L
- Abnormal coagulation values (INR greater than 1.5 not on warfarin and/or platelet count less than 100 x 10^9/L)
- Evidence of hepatic metabolic disorder (bilirubin greater than 35 mmol/L)
- Presence of active infection
- Preoperative autologous blood donation
- Use of erythropoietin during the index hospitalization not allowed
AI-Screening
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Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China, 210029
Actively Recruiting
Research Team
S
Shijiang Liu, MD
CONTACT
Y
Yue Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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