Fertility Preservation by Freezing Gonadal Tissue in Children and Young Adults at Risk for Early Ovarian Failure or Undergoing Gonad Removal

What this Trial Is About

Researchers are studying why people with Turner Syndrome, galactosemia, premature ovarian insufficiency POI, variations in sex characteristics, and those receiving high-risk gonadotoxic therapy have trouble getting pregnant or experience early menopause. The study aims to understand these conditions better and evaluate if freezing gonadal tissue can help preserve fertility in affected individuals. This observational study also explores the biological mechanisms causing follicle loss through advanced tissue analysis. Participants may undergo physical exams, blood tests, body measurements, and pelvic ultrasounds. Some may have surgery to remove gonadal tissue, which will be frozen and stored for future use. A portion of this tissue will be used for research to study follicles and gametes before and after freezing. The study includes multiple groups children and adolescents with various conditions at risk for ovarian dysfunction, including those who respond poorly to ovarian stimulation and those undergoing prophylactic gonadectomy. Participants will have follow-up visits including a checkup six weeks after surgery and additional visits up to 18 months post-surgery, with phone follow-ups every 12 to 24 months. Researchers will assess tissue quality, hormone levels, and gene expression to understand follicle loss and preservation. The study lasts 30 years, tracking long-term outcomes and potential complications related to fertility preservation and gonadal tissue cryopreservation.

Gonadal Tissue Freezing for Fertility Preservation in Individuals at Risk for Ovarian Dysfunction, Premature Ovarian Insufficiency and Clinically Indicated Gonadectomy