Comparing Two Types of An Gong Niuhuang Wan to Help Recovery After Traumatic Brain Injury in Adults Aged 18 to 60

What this Trial Is About

Traumatic brain injury TBI is a common neurosurgical condition that can severely impact a patients life and quality of life. Patients recovering from TBI often face serious neurological problems, consciousness issues, and systemic inflammatory responses. This trial studies the use of Jian Min Da Peng An Gong Niu Huang Wan, a version of a traditional Chinese medicine containing lab-grown cow bile, to support recovery of consciousness and cognitive functions after TBI. This approach aims to offer a more affordable and consistent treatment compared to traditional formulations. The trial compares two groups receiving oral medication one group takes Jian Min Da Peng An Gong Niu Huang Wan, and the other takes Tong Ren Tang An Gong Niu Huang Wan. Both are given once daily for one week, with administration by mouth or through a feeding tube if patients cannot eat independently. This study evaluates how well the newer formulation promotes neurological recovery after surgery for traumatic brain injury, addressing previous limitations with natural cow bile supply and drug consistency. Participants will have their neurological status assessed using Glasgow Coma Scale GCS scores before and after treatment at one and two weeks. Inflammatory markers, brain injury indicators, and imaging with MRI and CT scans will also be monitored. The study lasts at least two weeks for primary outcome measurement, focusing on neurological function improvement, with ongoing safety assessments and comparison between the two treatment groups.

An Gong Niuhuang Wan Promotes the Postoperative Neurological Function Recovery of Patients With Traumatic Brain Injury