Actively Recruiting
An Gong Niuhuang Wan Promotes the Postoperative Neurological Function Recovery of Patients With Traumatic Brain Injury
Led by Huaqiu Zhang · Updated on 2025-07-20
60
Participants Needed
1
Research Sites
159 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Clinical Challenges and Severity of Traumatic Brain Injury: Traumatic brain injury, as a common neurosurgical disease, poses a significant threat to patients' life safety and quality of life.The promotion of in vitro cultivated cow bile in the treatment of post-traumatic brain injury is expected to provide a more economical and effective treatment option for the recovery of consciousness and cognitive functions of TBI patients. Compared with traditional An Gong Niu Huang Wan, Jian Min Da Peng's An Gong Niu Huang Wan (containing in vitro cultivated cow bile) can not only reduce treatment costs, but also improve the stability and consistency of the quality of the drug. The above clinical research can provide scientific basis for including it in relevant treatment guidelines.
CONDITIONS
Official Title
An Gong Niuhuang Wan Promotes the Postoperative Neurological Function Recovery of Patients With Traumatic Brain Injury
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with brain trauma
- Age between 18 and 60 years inclusive
- Within three days after injury or surgery, with stable vital signs and condition
- Glasgow Coma Scale (GCS) score between 6 and 12, with consciousness disorder
- No contraindications for taking artificial or natural rhinoceros bile
You will not qualify if you...
- Recent use of other awakening drugs
- Consciousness disorders caused by traditional Chinese medicine-induced cold closure of the mind
- Open head trauma with clear intracranial infection
- Severe complications in other organs like pneumonia or gastrointestinal bleeding
- History of other neurological diseases
- Uncontrolled or unstable severe acute or chronic diseases in various systems including heart, diabetes, hypertension, blood, digestive, respiratory, autoimmune diseases
- Liver function with ALT or AST at least 2 times upper limit, total bilirubin over 1.5 times upper limit
- Kidney function with creatinine over 2 times upper limit
- Abnormal coagulation function (PT or APTT prolonged over 3 seconds, platelet count below 30 x 10^9/L)
- Pregnant or breastfeeding women
- Unable to undergo subsequent assessments
- Considered unsuitable by researchers to participate in the trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tongji hospital
Wuhan, Hubei, China, 430030
Actively Recruiting
Research Team
H
Huaqiu Zhang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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