Actively Recruiting
The Effect of Gradual Versus Intermittent Release of Tourniquet on Mean Arterial Blood Pressure in Hypertensive Patients Undergoing Upper Limb Orthopedic Surgeries: A Blinded Randomized Controlled Study
Led by Kasr El Aini Hospital · Updated on 2025-12-18
68
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating two different tourniquet deflation methods and their effects on blood pressure and blood chemistry in adults with hypertension undergoing upper limb orthopedic surgeries under general anesthesia. The study aims to understand how these techniques impact hemodynamics and acid-base balance in this specific group. The trial is a randomized, blinded controlled study designed to compare gradual versus intermittent tourniquet release in hypertensive patients. Participants will receive general anesthesia with drugs like propofol, fentanyl, and atracurium, and their breathing will be supported with mechanical ventilation. After the surgical procedure, the tourniquet will be released either gradually over 3 minutes or intermittently in cycles of deflation and reinflation. If surgery lasts longer than two hours, the intermittent method is used. A dose of lidocaine is given before inflating the tourniquet to help control blood pressure spikes. During the study, researchers will monitor blood pressure five minutes after tourniquet release and check acid-base status, lactate, and potassium levels at specified times. The anesthesia team and data collectors are blinded to the deflation method to ensure unbiased results. Participants will be closely observed throughout the procedure and recovery, with detailed measurements taken to assess the clinical effects of the deflation techniques.
CONDITIONS
Brief Title
Gradual Versus Intermittent Release of Tourniquet Effect on MAP in Hypertensive Patients Undergoing Upper Limb Orthopedic Surgeries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hypertensive patients treated with medication for more than three months
- Scheduled for upper limb orthopedic surgery using a tourniquet for at least 30 minutes
- Body mass index (BMI) between 18.5 and 29.9
You will not qualify if you...
- Patient refusal to participate
- ASA physical status greater than II
- Multiple orthopedic surgeries planned
- Emergency surgeries
- Relative contraindications for tourniquet use
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Surgery duration plus up to 3 minutes for tourniquet deflation
Participants undergo upper limb orthopedic surgery with general anesthesia and tourniquet application. The tourniquet deflation technique is applied either gradually or intermittently as part of the study intervention.
1 surgical visit (in-person)
Duration - Up to 30 minutes post-surgery
Participants are monitored for hemodynamics and laboratory parameters including mean arterial pressure, acid base status, lactate, and potassium levels following surgery and tourniquet deflation.
1 follow-up visit (in-person)
Trial Site Locations
Total: 1 location
1
Cairo university hospitals
Cairo, Egypt
Actively Recruiting
Research Team
K
Khaled Sarhan, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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