Investigating Vein Graft Failure and Heart Complications After Coronary Artery Bypass Surgery Using Advanced PET-CT Imaging

What this Trial Is About

Researchers are investigating the causes and effects of saphenous vein graft failure following coronary artery bypass graft CABG surgery. This observational cohort study focuses on understanding inflammation, thrombosis, and fibrosis in vein grafts after surgery. It includes two groups patients recently undergoing CABG with at least one vein graft and patients with prior CABG at least 5 years ago who show symptoms suggesting vein graft failure. The study aims to provide insight into complications like heart attacks and strokes after CABG surgery. Participants will undergo advanced imaging using total-body positron emission tomography and computed tomography PET-CT combined with coronary computed tomography angiography to observe the vein grafts, heart, brain, and other body areas. The first group will be scanned within 28 days of their surgery and again after 12 months, while the second group will have imaging prior to their clinical invasive coronary angiography. Additional assessments include an echocardiogram and blood tests, with blood samples taken for immediate and future analysis. The study will enroll up to 150 participants and last for 36 months. During this time, participants will have clinical reviews, imaging scans, blood sampling, and follow-up visits. Researchers will measure platelet, fibroblast, and macrophage activation over three years, along with systemic cardiovascular disease. The studys goal is to better understand vein graft failure and its cardiovascular consequences after CABG surgery.

Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery