Actively Recruiting
Vein Graft Failure and Cardiovascular Consequences of Coronary Artery Bypass Graft Surgery
Led by University of Edinburgh · Updated on 2026-04-20
70
Participants Needed
1
Research Sites
18 weeks
Total Duration
On this page
Sponsors
U
University of Edinburgh
Lead Sponsor
N
NHS Lothian
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the causes and effects of saphenous vein graft failure following coronary artery bypass graft (CABG) surgery. This observational cohort study focuses on understanding inflammation, thrombosis, and fibrosis in vein grafts after surgery. It includes two groups: patients recently undergoing CABG with at least one vein graft and patients with prior CABG (at least 5 years ago) who show symptoms suggesting vein graft failure. The study aims to provide insight into complications like heart attacks and strokes after CABG surgery. Participants will undergo advanced imaging using total-body positron emission tomography and computed tomography (PET-CT) combined with coronary computed tomography angiography to observe the vein grafts, heart, brain, and other body areas. The first group will be scanned within 28 days of their surgery and again after 12 months, while the second group will have imaging prior to their clinical invasive coronary angiography. Additional assessments include an echocardiogram and blood tests, with blood samples taken for immediate and future analysis. The study will enroll up to 150 participants and last for 36 months. During this time, participants will have clinical reviews, imaging scans, blood sampling, and follow-up visits. Researchers will measure platelet, fibroblast, and macrophage activation over three years, along with systemic cardiovascular disease. The study's goal is to better understand vein graft failure and its cardiovascular consequences after CABG surgery.
CONDITIONS
Brief Title
Graft Failure and Consequences of Coronary Artery Bypass Graft Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years of age or older
- Patients undergoing CABG surgery for multivessel coronary artery disease with at least one saphenous vein graft
- Patients who had CABG surgery 5 or more years ago for multivessel disease with two or more saphenous vein grafts
- Patients referred for invasive coronary angiography due to symptoms and suspected graft vasculopathy
You will not qualify if you...
- Patients with a life expectancy less than 2 years
- Patients with severe kidney failure (estimated glomerular filtration rate less than 30 mL/min/1.73 m2)
- Patients on immunosuppressive therapies
- Pregnant or breastfeeding females of child-bearing age
- Known allergy or contraindication to iodinated contrast or radiotracer
- Patients unable to tolerate lying flat (supine position)
- Patients unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 28 days before or after coronary artery bypass graft (CABG) surgery for Cohort 1, or prior to invasive coronary angiography for Cohort 2
Participants undergo clinical review including blood sampling, transthoracic echocardiogram, total-body positron emission tomography computed tomography (PET-CT) imaging, and CT coronary angiography to assess graft status.
1 to 2 visits depending on cohort
Duration - 12 months
Participants are followed over time with repeat imaging and clinical assessments to monitor inflammation, thrombosis, fibrosis, and graft function.
1 follow-up visit at 12 months
Trial Site Locations
Total: 1 location
1
Royal Infirmary of Edinburgh
Edinburgh, Midlothian, United Kingdom, EH16 4SA
Actively Recruiting
Research Team
L
Laura E Clark, BSc, MBChB, MRCS(Ed)
D
David E Newby, BSc (Hons) PhD BM DM DSc FRCP
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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