Actively Recruiting
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1
Led by Yale University · Updated on 2026-01-29
12
Participants Needed
1
Research Sites
152 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
V
VA Connecticut Healthcare System
Collaborating Sponsor
AI-Summary
What this Trial Is About
The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared. Each Veteran participant will be randomized to receive three different concentrations, which will be injected one week apart each.
CONDITIONS
Official Title
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1
Who Can Participate
Eligibility Criteria
You may qualify if you...
- United States Military Veterans within VA Connecticut Healthcare System
- Chronic post-traumatic headache per ICHD-3 criteria with headaches continuing at least three months after head injury
- At least two headache days per week
- MRI brain scan completed within the past 3 months if chronic PTH duration is less than one year
- MRI brain scan completed within the past year if chronic PTH duration is less than 5 years
- MRI brain scan completed within 5 years if chronic PTH duration is more than 10 years
- Review of MRI and medical records shows no other source of headache
You will not qualify if you...
- Skull defect
- Allergy or adverse reaction to amide anesthetics like lidocaine
- Instruction from a clinician to avoid amide anesthetics like lidocaine
- Pregnancy or lack of adequate birth control
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
VA Connecticut Healthcare System
West Haven, Connecticut, United States, 06516
Actively Recruiting
Research Team
E
Emmanuelle Schindler, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
4
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