Study of Green Tea and Quercetin With Docetaxel Chemotherapy for Men With Advanced Prostate Cancer

What this Trial Is About

Researchers are evaluating whether adding natural products green tea and quercetin to docetaxel chemotherapy improves treatment for advanced prostate cancer called metastatic castration-resistant prostate cancer mCRPC. The study also aims to assess the safety of combining these supplements with docetaxel. This is a Phase III randomized clinical trial sponsored by Charles Drew University of Medicine and Science. Participants will receive either green tea and quercetin capsules along with docetaxel chemotherapy or placebo capsules with docetaxel for comparison. The treatments are given in cycles, and the study is designed to compare how the supplements affect the therapys effectiveness and safety. The trial uses a quadruple masking method to protect unbiased results. During the study, researchers will monitor participants by measuring blood prostate specific antigen PSA levels from enrollment until 11 weeks, along with tumor DNA levels, tumor size via CT scans, and side effects using standard criteria. Blood levels of green tea, quercetin, and docetaxel will also be analyzed on the first day of the first treatment cycle. The total duration of treatment and assessments is approximately 11 weeks.

Green Tea and Quercetin in Combination With Docetaxel Chemotherapy in Castration-resistant Prostate Cancer Patients