Actively Recruiting
GRID Therapy as Palliative Radiation for Patients With Advanced and Symptomatic Tumors
Led by Sir Mortimer B. Davis - Jewish General Hospital · Updated on 2026-05-12
50
Participants Needed
1
Research Sites
673 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Palliative radiation therapy represents 40% of the on-going radiation at the Jewish General Hospital. In a traditional palliative radiation treatment to bulky or radioresistant tumors, radiotherapy schema varies from 24 to 30 Gys given in 3 to 10 fractions, depending on the tumor size, tumor location and tumor pathology. However, for many patients this treatment involves considerable toxicity, travel and time spent at the hospital. Spatially fractionated radiation (SFR) is an alternative technique that consists in delivering one single treatment, given through a grid containing holes. The present study is proposing to validate SFR as a safe and effective mean to palliate patients with symptomatic bulky tumors (more than 8 cm) or with tumors known to be resistant to radiation.
CONDITIONS
Official Title
GRID Therapy as Palliative Radiation for Patients With Advanced and Symptomatic Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient with histologically or cytologically confirmed malignancy. All malignant histologies/cytologies are eligible.
- Patient with bulky tumor (larger than 8cm), or with a tumor known to be resistant to radiation (eg. Melanoma, hypernephroma, sarcoma), or with a tumor previously irradiated with a palliative intent requiring more than 1 fraction of radiation
- Patient planned to undergo palliative radiation therapy treatments to one of the following 5 sites: extremities, neck, chest, abdomen and pelvis
- WHO performance status of 0-2
- Aged 18 years or older
- Ability to sign and understand an informed consent form
You will not qualify if you...
- Potentially curable patient
- Previous palliative radiation with hypofractionation
- Tumor located near the spinal cord or in the brain
- Pregnant or nursing woman
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Sir Mortimer Jewish General Hospital
Montreal, Quebec, Canada, H3T 1E2
Actively Recruiting
Research Team
L
Luciana Poggi, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
1
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