Actively Recruiting
Growth Hormone Resistance of Beta-cells A
Led by University of Missouri-Columbia · Updated on 2026-05-11
30
Participants Needed
1
Research Sites
253 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes.
CONDITIONS
Official Title
Growth Hormone Resistance of Beta-cells A
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Singleton, full term pregnancy within the past 5 years
- Body mass index 18.5 kg/m2 and <45.0 kg/m2
- Gestational Diabetes Group: History of gestational diabetes in the most recent pregnancy
- Control Group: No history of gestational diabetes
You will not qualify if you...
- Pregnant, planning to become pregnant during the study, or breastfeeding
- Current diagnosis or history of type 1 or type 2 diabetes
- Use of medications that can impact the study outcomes (e.g., GLP-1 receptor agonists)
- History of bariatric surgery
- Known, uncontrolled hypothyroidism
- History of intracranial hypertension, including papilledema, or a condition that increases the risk of developing intracranial hypertension, such as Turner Syndrome, Prader-Willi Syndrome, or renal impairment
- Current cancer or cancer that has been in remission less than 5 years
- First degree relative with diabetes diagnosis
- Evidence of significant anemia or significant end organ dysfunction (e.g., liver, kidney, heart disease)
- Alcohol use disorder, use of controlled substances, or smoking >2 cigarettes per day
- Greater than 3% weight loss within three months of screening or engaged in regular ( 3 days per week), continuous moderate- or high-intensity exercise of 30 min duration
- Mentally disabled persons, prisoners, and persons with inability to grant voluntary informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Missouri School of Medicine
Columbia, Missouri, United States, 65212
Actively Recruiting
Research Team
A
Amanda Heider
CONTACT
V
Vasavi Shabrish, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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