Actively Recruiting
Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes
Led by University of Missouri-Columbia · Updated on 2026-05-11
30
Participants Needed
1
Research Sites
267 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a family history of type 2 diabetes at the University of Missouri. Our aim is to advance understanding of how growth hormone affects beta-cells and risk factors for developing type 2 diabetes.
CONDITIONS
Official Title
Growth Hormone Resistance of Beta-cells in People With a Family History of Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 59 years
- Body mass index (BMI) between 30.0 and less than 45.0 kg/m2
- Family history of type 2 diabetes with a first-degree relative having type 2 diabetes (for study group)
- No family history of type 2 diabetes (for control group)
You will not qualify if you...
- Pregnant, planning to become pregnant during the study, or breastfeeding
- Current diagnosis or history of type 1 or type 2 diabetes
- Use of medications that can affect study outcomes, such as GLP-1 receptor agonists
- History of bariatric surgery
- Known uncontrolled hypothyroidism
- History of intracranial hypertension or related conditions like Turner Syndrome, Prader-Willi Syndrome, or renal impairment
- Current cancer or cancer in remission less than 5 years
- First-degree relative diagnosed with type 1 diabetes
- Significant anemia or serious organ dysfunction (liver, kidney, heart)
- Alcohol use disorder, use of controlled substances, or smoking more than 2 cigarettes per day
- More than 3% weight loss in past three months or regular moderate/high intensity exercise 3 or more days per week for 30 minutes or more
- Mentally disabled persons, prisoners, or those unable to provide voluntary informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Missouri School of Medicine
Columbia, Missouri, United States, 65212
Actively Recruiting
Research Team
A
Amanda Heider
CONTACT
V
Vasavi Shabrish, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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