Actively Recruiting
GT719 Injection for the Treatment of Recurrent/Refractory CD19 Positive Adult B-cell Malignancies
Led by Grit Biotechnology · Updated on 2025-09-16
46
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
Sponsors
G
Grit Biotechnology
Lead Sponsor
I
Institute of Hematology & Blood Diseases Hospital, China
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study is a prospective single-arm open-labled phase I/II clinical trial, including dose escalation and expansion phase, aims to evaluate the safety, efficacy, and cellular pharmacokinetics of GT719 Injection in relapsed/refractory CD19 positive adult B-cell non Hodgkin lymphoma (B-NHL) and B-acute lymphoblastic leukemia (B-ALL) patients. A total of 46 subjects (anticipated) will be enrolled in this study.
CONDITIONS
Official Title
GT719 Injection for the Treatment of Recurrent/Refractory CD19 Positive Adult B-cell Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntarily enrolled in the study, signed informed consent, and willing to follow the study plan
- Eastern Collaborative Oncology Group (ECOG) physical fitness status score of 0 or 1
- Confirmed CD19 positivity by flow cytometry or histopathology
You will not qualify if you...
- Primary immunodeficiency
- Symptomatic deep vein thrombosis or pulmonary embolism within 6 months before enrollment requiring anticoagulant therapy
- Any medical condition that could interfere with evaluating safety or treatment effectiveness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences
Tianjin, Tianjin Municipality, China
Actively Recruiting
Research Team
D
Dehui Zou
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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