Actively Recruiting
Guanfacine for Alcohol Use Disorder (AUD)
Led by Indiana University · Updated on 2026-05-11
200
Participants Needed
2
Research Sites
205 weeks
Total Duration
On this page
Sponsors
I
Indiana University
Lead Sponsor
N
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators assess whether guanfacine extended release (GXR; 3mg/d) compared with placebo (PBO) will attenuate drinking and drinking-related factors in N=200 men and women with Alcohol Use Disorder (AUD) across 12-weeks.
CONDITIONS
Official Title
Guanfacine for Alcohol Use Disorder (AUD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Assigned as biological male or female at birth and identify as such
- Meet current DSM V criteria for moderate to severe Alcohol Use Disorder
- Be 18 years or older with a body mass index (BMI) of 18-35
- Express desire to quit alcohol as determined by the SOCRATES scale
- Have a positive urine test for alcohol on admission to study procedures
- Able to provide informed verbal and written consent
- Able to read English and complete study evaluations
- Be in good health as verified by intake physical examination
You will not qualify if you...
- Meet criteria for moderate to severe Substance Use Disorder excluding alcohol and nicotine
- Have a positive screen for substances of abuse excluding alcohol and nicotine
- Be psychotic or severely psychiatrically disabled including suicidal, homicidal, or current mania
- Require medical detoxification for physiological dependence on alcohol
- Regular use of medications in last 6 months contraindicated with guanfacine XR
- Be pregnant or breastfeeding
- Use monophasic contraceptives
- Have cardiovascular disease including high blood pressure
- Have hypotension with sitting blood pressure below 100/50 mmHg
- Have bradycardia with sitting heart rate below 60 bpm
- Show clinically significant EKG conduction abnormalities including QTc over 470 msec for women and over 450 msec for men
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
The Stark Neuroscience Building (Goodman Hall)
Indianapolis, Indiana, United States, 46202
Actively Recruiting
2
Rutgers School of Health Professionals
Newark, New Jersey, United States, 07107
Actively Recruiting
Research Team
H
Helen C Fox, PhD
CONTACT
M
Mitch Smith
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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