Guideline-Oriented Lipid Lowering Approach for Adults with Cardiovascular Diseases in Asia-Pacific A Randomized Study Comparing Early and Late Intervention Using Patient and Clinician Score Cards

What this Trial Is About

This research aims to evaluate a guideline-oriented approach to lipid lowering in patients hospitalized with Type I myocardial infarction across the Asia-Pacific region. The study uses a randomized, multi-phase design to compare an early multifaceted intervention against standard care, with a focus on improving lipid management and patient engagement. It is designed to reflect real-world clinical practice by embedding the intervention within routine care. Participants are randomly assigned to receive the intervention either early, at baseline continuing through 6 months, or late, after 6 months. The intervention includes a patient-and-clinician cholesterol score card to track LDL cholesterol levels, medication adherence, clinician decisions, and prescribed therapies. Additionally, risk stratification using a SMART Risk score and Lpa measurement is provided to both patients and their primary care clinicians. Those in the late group receive standard-of-care during the first 6 months, which involves regular lipid profile reporting to their general practitioner. Participants will be involved in follow-up visits during the study where the score card is updated and adherence, lipid levels, and treatment changes are monitored. Primary outcomes include the proportion of patients achieving LDL cholesterol levels below 1.4 mmolL at 6 months. Secondary outcomes assess lipid therapy intensification, statin use, and patient activation. The study spans 12 months, with the late group receiving the intervention after the initial 6-month control period, and ongoing follow-up to measure treatment effects and adherence.

Guideline Oriented Approach To Lipid Lowering In Asia-Pacific