Actively Recruiting
GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing ctDNA Diagnostics - Colorectal Cancer
Led by Claus Lindbjerg Andersen · Updated on 2026-05-04
590
Participants Needed
15
Research Sites
417 weeks
Total Duration
On this page
Sponsors
C
Claus Lindbjerg Andersen
Lead Sponsor
M
Medical University of Graz
Collaborating Sponsor
AI-Summary
What this Trial Is About
Improving personalized cancer treatments and finding the best strategies to treat each patient relies on using new diagnostic technologies. Currently, for colorectal cancer, the methods used to decide who gets additional post-surgery treatment are suboptimal. Some patients get too much treatment, while others do not get enough. There is a new way to explore if there is any cancer left in a patient's body using circulating tumor DNA (ctDNA) detected in blood samples. This can help decide who needs more treatment after surgery. Even though many tests have been developed, it has yet to be determined which test performs best at relevant time points. The GUIDE.MRD consortium is a group of experts, including scientists, technology, and pharmaceutical companies. The consortium is working on creating a reliable standard for the ctDNA tests, validating their clinical utility, and collecting data to help decide on the best treatment for each patient. GUIDE.MRD-01-CRC is a part of the GUIDE.MRD project.
CONDITIONS
Official Title
GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing ctDNA Diagnostics - Colorectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Colorectal cancer, UICC stage III
- Received curative-intent surgery and candidate for adjuvant chemotherapy
- Able to understand and sign informed consent
- Colorectal cancer liver metastasis
- Planned for curative-intent treatment
- Performance status 0-1
You will not qualify if you...
- Hereditary colorectal cancer linked to familial colonic polyposis or Lynch syndrome
- Inflammatory bowel disease (Crohn's disease or ulcerative colitis)
- Verified distant metastases
- Not treated with adjuvant chemotherapy despite indication
- Treated with neoadjuvant chemo-radiation therapy
- No tissue sample available or tumor content <20%
- Synchronous colorectal and non-colorectal cancer diagnosed per operative (except skin cancer other than melanoma)
- Other cancers (excluding colorectal or certain skin cancers) within 3 years
- Unlikely to comply with the study protocol
- Liver cirrhosis
- Extrahepatic metastases
- Other cancer within last 5 years
- Intervention not performed with curative intent
- No tissue available from liver metastases or primary tumor
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 15 locations
1
Abteilung für Onkologie, Medizinische Universität Graz
Graz, Styria, Austria, 8010
Actively Recruiting
2
Ordenskrankenhaus Graz Mitte
Graz, Styria, Austria, 8010
Actively Recruiting
3
Bispebjerg Hospital
Copenhagen, Capital Region of Denmark, Denmark, 2400
Actively Recruiting
4
Herlev Hospital
Herlev, Capital Region of Denmark, Denmark, 2730
Not Yet Recruiting
5
Aarhus University Hospital
Aarhus, Central Jutland, Denmark, 8000
Actively Recruiting
6
Gødstrup Hospital
Herning, Central Jutland, Denmark, 7400
Actively Recruiting
7
Regional Hospital Horsens
Horsens, Central Jutland, Denmark, 8700
Actively Recruiting
8
Regional Hospital Randers
Randers, Central Jutland, Denmark, 8930
Actively Recruiting
9
Regional Hospital Viborg
Viborg, Central Jutland, Denmark, 8800
Actively Recruiting
10
Aalborg University Hospital
Aalborg, North Denmark, Denmark, 9000
Actively Recruiting
11
Odense University Hospital
Odense, The Region of Southern Denmark, Denmark, 5000
Actively Recruiting
12
LCCRH (Laboratoire Cellules Circulantes Rares Humaines) - CHU de Montpellier
Montpellier, France, 34295
Actively Recruiting
13
Department of General-, Visceral- and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
Hamburg, Free and Hanseatic City of Hamburg, Germany, 20246
Actively Recruiting
14
Universitätsklinikum Hamburg-Eppendorf
Hamburg, Free and Hanseatic City of Hamburg, Germany, 20246
Actively Recruiting
15
Karolinska University Hospital
Huddinge, Stockholm County, Sweden, 14183
Actively Recruiting
Research Team
C
Claus L Andersen, PhD
CONTACT
M
Mads H Rasmussen, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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