Impact of a High-Fat Meal and Inulin Supplement on Gut, Immune, and Vascular Health in Adults with Metabolically Healthy Obesity and Normal Weight

What this Trial Is About

Researchers are studying how a single high-fat meal affects gut, immune, and vascular health in people with metabolically healthy obesity and those with a normal weight but similar metabolic profiles. They also want to understand how taking a prebiotic fiber called inulin influences these health aspects in individuals with metabolically healthy obesity. This project includes two parts under one study approval, focusing on these specific groups and health markers. In part 1, participants with normal or obese body mass index BMI will complete a high-fat meal trial involving blood samples and vascular tests at multiple time points before and after the meal. The meal contains about 700 calories from fat, chocolate syrup, and protein powder. Part 2 involves only participants with obesity who will be randomized to receive either inulin supplements or a placebo for six weeks. Blood samples, stool samples, and vascular assessments will be collected at baseline and during follow-up visits. Participants will have various measurements taken, including blood tests to check biomarkers of inflammation and intestinal health, vascular function tests, and stool samples to analyze gut microbiome. Blood will be drawn multiple times within hours after the meal in part 1 and at intervals during the six-week supplement phase in part 2. The study will track changes in these markers over time to evaluate the impact of diet and supplementation on gut, immune, and vascular health. Participation may last up to two years for some outcome assessments.

Gut, Immune, and Vascular Health in Metabolically Healthy Obesity