Actively Recruiting
Gut Kidney Axis in Enteric Hyperoxaluria
Led by NYU Langone Health · Updated on 2026-05-07
80
Participants Needed
1
Research Sites
276 weeks
Total Duration
On this page
Sponsors
N
NYU Langone Health
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
40 subjects with a confirmed diagnosis of IBD or \>6 months post-RYGB with a diagnosed USD event or kidney stone on imaging within the past three years and 40 healthy controls will be administered a high oxalate diet on Days 0-3 and Days 21-24 with a washout period on Days 4-7 and will be administered 250mg sodium oxalate on Days 8-20, via prepared spinach, from Weil Cornell Medicine's Clinical and Translational Science Center. Subjects will partake in four stool collections, four 24-h urine collections, two blood collections, and four sets of colonic permeability testing.
CONDITIONS
Official Title
Gut Kidney Axis in Enteric Hyperoxaluria
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Subjects between 18 and 80 years of age
- Confirmed diagnosis of inflammatory bowel disease or more than 6 months after Roux-en-Y gastric bypass surgery, with a kidney stone event or stone seen on imaging in the last three years
- Includes all races and ethnicities, both men and women
- Healthy controls must be between 18 and 80 years old
- Healthy controls must have no chronic diseases, no chronic medications, no history of gastrointestinal problems or kidney stones
- Includes all races and ethnicities, both men and women
You will not qualify if you...
- Pregnant or nursing women
- People with medical, psychiatric, or debilitating conditions or social situations that prevent following the study or giving consent
- People who had total or partial colectomy
- People who took antibiotics by mouth, injection, or intravenously within the last three months
- Patients with perianal disease who often take antibiotics
- Patients with an active or recent (within 3 months) flare of inflammatory bowel disease
- Patients with kidney function below an estimated glomerular filtration rate of 60 ml/min/1.73 m2 measured in the past year
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
NYU Langone Health
New York, New York, United States, 10016
Actively Recruiting
Research Team
L
Lama Nazzal, MD
CONTACT
D
David Goldfarb, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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