Actively Recruiting
Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers
Led by University of Virginia · Updated on 2025-03-27
104
Participants Needed
1
Research Sites
136 weeks
Total Duration
On this page
Sponsors
U
University of Virginia
Lead Sponsor
N
National Institute on Aging (NIA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Spousal caregivers of Alzheimer's Dementia (AD) patients have an elevated risk of developing AD in the future. Past studies have shown the presence of serum indicators correlated with gut biome dysfunction in AD patients. We hypothesize that the same gut biome dysfunction may be present in spousal caregivers of AD patients.
CONDITIONS
Official Title
Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with Alzheimer's disease whose clinical dementia rating (CDR) is greater than 1
- Spouses of patients with Alzheimer's disease
- Healthy adults unrelated to the above groups with no history of dementia
- All participants must be between 65 and 90 years old
You will not qualify if you...
- Familial Alzheimer's disease
- Severe cardiovascular disease
- Severe respiratory system disease
- Severe liver disease
- Severe kidney disease
- Severe central nervous system diseases
- Life expectancy fewer than 3 months
- History of psychiatric illness
- Major neurological diseases other than Alzheimer's disease
- Current use of corticosteroids, antibiotics, or bowel motility modification agents
- History of alcoholism or illicit drug dependence
- Previous participation in this study
- Difficulty with follow-up or poor compliance
- Severe hearing impairment
- Severe vision impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Virginia
Charlottesville, Virginia, United States, 22908-0710
Actively Recruiting
Research Team
K
Keita Ikeda, PHD
CONTACT
Z
ZHIYI ZUO, MD PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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