Study on Gut Microbiome and Metabolome Changes in Adults With Gallstone Disease Undergoing Gallbladder Surgery and Possible Bile Duct Procedures

What this Trial Is About

Researchers are studying changes in the gut microbiome and systemic metabolome in patients with symptomatic gallbladder stones, with or without bile duct stones, who will undergo gallbladder removal surgery cholecystectomy and possibly endoscopic procedures like ERCP-ES. This observational study aims to see if there are differences in gut microbiome diversity and metabolome profiles before and after surgery, and how these profiles change over time. Participants will provide stool, urine, plasma, and saliva samples before surgery and again between 1 to 6 months after cholecystectomy. Patients who have bile duct stones and undergo ERCP-ES before surgery will also have bile samples collected during the procedure and surgery. Clinical data and biospecimens will be analyzed to assess microbiome and metabolome changes, comparing results to matched control groups and patients with longer-term post-surgery duration. During follow-up clinic visits 1 to 6 months after surgery, patients will be evaluated for symptoms like post-cholecystectomy syndrome or diarrhea. Researchers will perform metagenomic sequencing and metabolomic analysis on collected samples to measure gut and bile microbiome profiles and systemic metabolome changes. The study duration allows for monitoring changes over several months after surgery to better understand the impact of these interventions.

Gut Microbiome and Metabolome in Patients With Gallstone Disease After Surgical and Endoscopic Interventions