Actively Recruiting
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
Led by Jena University Hospital · Updated on 2024-12-30
100
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
J
Jena University Hospital
Lead Sponsor
U
University of Jena
Collaborating Sponsor
AI-Summary
What this Trial Is About
Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis. The proposal aims to combine holistic approaches with emerging experimental technologies to investigate the complex interactions between the gut microbiota and its host and assess the impact of specific bacterial communities on longevity and stress responses. A strong focus of this study will also be placed on microbiome dysbiosis and secondary impacts on short- and long-term brain dysfunction using clinical, laboratory and imaging procedures.
CONDITIONS
Official Title
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 218 years
- Critically ill patients treated with meropenem or piperacillin/tazobactam started within the last 72 hours
- Critically ill patients without systemic antimicrobial therapy within the last 72 hours and expected ICU stay longer than 3 days
- Long-term survivors of sepsis from existing sepsis cohorts
You will not qualify if you...
- Inflammatory bowel disease
- Major bowel resection
- Use of selective decontamination of the oral and digestive tract
- Oral vancomycin therapy
- Immunocompromised status
- Chemotherapy within the last 6 months
- Recent travel to high antimicrobial resistance areas (except USA and Canada) within 4 weeks
- Acute neurological diseases such as brain ischemia, hemorrhage, meningoencephalitis, tumor
- Manifest dementia or pre-existing psychiatric diseases like schizophrenia or psychosis
- Recent acute brain surgery
- MRI contraindications including pacemakers, implants, pregnancy, claustrophobia, or extensive tattoos
AI-Screening
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Trial Site Locations
Total: 1 location
1
Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Jena
Jena, Thuringia, Germany, 07747
Actively Recruiting
Research Team
J
Johannes Ehler, Priv.-Doz. Dr. med.
CONTACT
K
Katrin Ludewig, Dr. med.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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