Actively Recruiting
Gut Microbiota in Chronic GI Diseases
Led by McMaster University · Updated on 2024-08-01
260
Participants Needed
1
Research Sites
734 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The study involves characterizing the microbiota of patients with IBS, functional diarrhea, IBD, severe motility disorders and celiac disease. This will be complemented by a translational phase of human-mouse hybrid experiments in which germ-free mice will be colonized with feces from these patients with different GI disease and non-disease controls and we will compare symptoms, microbiota composition and histological changes in the gut and in the brain of the mice.
CONDITIONS
Official Title
Gut Microbiota in Chronic GI Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of IBD, active celiac disease (aTTG positive plus endoscopic and histological findings), IBS (Rome IV criteria or physician diagnosis), severe motility disorders (severe constipation or severe functional dyspepsia), gluten sensitivity (IBS diarrhea-predominant with positive anti-gliadin antibodies and negative aTTG), functional diarrhea (Rome IV criteria), anal fissure and/or fistula, or non-disease control or first-degree family member of a celiac patient
- Willingness to participate
- Signed informed consent
You will not qualify if you...
- Use of antibiotics in the last month
- Use of probiotics in the previous month
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
McMaster University
Hamilton, Ontario, Canada, L8S 4L8
Actively Recruiting
Research Team
P
Premysl Bercik, MD
CONTACT
G
Gaston Rueda, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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