Actively Recruiting
Gut Microbiota-dependent Health Impacts of Haskap Berries
Led by Montana State University · Updated on 2025-04-02
120
Participants Needed
1
Research Sites
165 weeks
Total Duration
On this page
Sponsors
M
Montana State University
Lead Sponsor
M
Montana State Agricultural Experiment Station
Collaborating Sponsor
AI-Summary
What this Trial Is About
Polyphenol-rich Haskap berries (Haskap) have untapped therapeutic potential to improve human health, and agricultural producers in northern U.S. states are poised to increase production if consumer demand increases. A critical knowledge gap is that little is known about the interactions between gut microbes and Haskap polyphenols to produce bioactive metabolites linked to downstream health impacts. Additionally, little is known about which Haskap varieties and harvest timing yield the greatest bioactive potential. This study aims to address these gaps by investigating the interaction of bioactive components in Haskap with gut microbiota and the resultant gut and serum metabolites, inflammation, and metabolic health, and then couple this with analysis of berries from different Haskap varieties and harvest times.
CONDITIONS
Official Title
Gut Microbiota-dependent Health Impacts of Haskap Berries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 35 to 65 years
- For metabolically healthy group: waist circumference men 4, women 35 inches or less
- For metabolically healthy group: systolic blood pressure 30 mmHg or less
- For metabolically healthy group: diastolic blood pressure 5 mmHg or less
- For metabolically healthy group: fasting glucose 00 mg/dL or less
- For metabolically healthy group: fasting triglycerides 50 mg/dL or less
- For metabolically healthy group: HDL cholesterol men greater than 40 mg/dL, women greater than 50 mg/dL
- For metabolically unhealthy group: waist circumference men 40 inches or more, women 35 inches or more
- For metabolically unhealthy group: at least one of the following: systolic blood pressure greater than 130 mmHg, diastolic blood pressure greater than 85 mmHg, fasting glucose greater than 100 mg/dL, fasting triglycerides greater than 150 mg/dL, or HDL cholesterol men 40 mg/dL or less, women 50 mg/dL or less
You will not qualify if you...
- Body mass index less than 18 or greater than 40 kg/m2
- Allergy to Haskap or placebo ingredients
- Use of anti-inflammatory, lipid lowering, glucose lowering, blood pressure, or other medications that may affect study measures
- Pregnant or lactating women
- Diagnosis of type 1 or type 2 diabetes or any condition interfering with study measures
- Current cigarette smoker
- Antibiotic use within the past 90 days
- Use of supplements including prebiotics, probiotics, or "superfoods" within 30 days before study start
- Planning to start a weight loss or exercise regimen change
- Following a specific diet such as low carbohydrate, vegan, or vegetarian
- Consuming more than 5 servings of fruits or vegetables per day
- Unwillingness to reduce caffeine intake to one 8 oz serving per day during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Montana State University
Bozeman, Montana, United States, 59717
Actively Recruiting
Research Team
M
Mary P Miles, PhD
CONTACT
Z
Zachary T Miller, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here