Actively Recruiting
Gut Microbiota in IBD With Comorbid Depressive Disorder
Led by Fang Tang · Updated on 2026-01-23
120
Participants Needed
1
Research Sites
141 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Inflammatory bowel disease (IBD) is often comorbid with depressive disorder, and the development and progression of both conditions are closely related to the composition of gut microbiota and metabolites. However, studies investigating their comorbidity using microbiome and metabolomics approaches remain limited. This study aims to investigate the diversity changes in the gut microbiome and metabolome of patients with comorbid IBD and depressive disorder through multi-omics approaches, to identify specific microbial and metabolic signatures associated with the comorbidity of these two conditions, and to provide a molecular basis for elucidating the underlying mechanisms.
CONDITIONS
Official Title
Gut Microbiota in IBD With Comorbid Depressive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with inflammatory bowel disease (ICD-10 codes: K50-K51) with or without depressive disorder
- History of depressive disorder diagnosis or previous use of antidepressant medications (for IBD with depressive disorder group)
- No history of depressive disorder diagnosis and no previous use of antidepressant medications (for IBD without depressive disorder group)
- No history of inflammatory bowel disease, depressive disorder, or use of antidepressant medications (for control group)
- No gastrointestinal symptoms such as diarrhea, constipation, or abdominal pain within the past 3 months and no history of gastrointestinal diseases (for control group)
- Age 18 years or older
- Willingness to participate and provision of written informed consent
You will not qualify if you...
- Presence of other major chronic diseases or infections such as malignancy, hypertension, diabetes, or coronary heart disease
- Use of antibiotics or probiotic supplements within the past 6 months
- Inability or difficulty in providing biological samples
- Missing essential patient information
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
Jinan, Shandong, China, 250014
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here