Correlation Study Between Gut Microbiota and Prognosis in Patients With Intracranial Arterial Stenosis (GROW-ICAS)

What this Trial Is About

This observational study, GROW-ICAS, enrolls patients aged 30 to 80 years with intracranial arterial stenosis to examine how gut microbiota and related biological profiles relate to important clinical aspects. The research focuses on functional outcomes, vascular plaque imaging features, and post-stroke non-motor problems such as cognitive impairment, depression, anxiety, and fatigue. Researchers aim to better understand these connections to improve prognosis for affected patients. Participants do not receive specific treatments but are monitored to collect detailed data on their gut microbiota, metabolomic, and transcriptomic profiles alongside imaging and clinical assessments. The study follows patients for at least one year to observe stroke recurrence in those with symptomatic or asymptomatic intracranial arterial stenosis and changes in vascular plaque characteristics. There is no intervention; rather, the study observes natural progression and associations. During the study, participants undergo imaging scans to confirm intracranial arterial stenosis and regular evaluations to assess functional status, cognitive and emotional health, and vascular plaque changes. Researchers collect biological samples and clinical data to analyze correlations with outcomes. Safety and eligibility are assessed by excluding those with recent bleeding, other major medical conditions, or treatments that might interfere. The overall participation spans at least one year from enrollment with ongoing monitoring of stroke events and vascular health.

Gut Microbiota and Prognostic Outcomes in Intracranial Arterial Stenosis Patients（GROW-ICAS）